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Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A.
Kuznetsov G, Xu Q, Rudolph-Owen L, Tendyke K, Liu J, Towle M, Zhao N, Marsh J, Agoulnik S, Twine N, Parent L, Chen Z, Shie JL, Jiang Y, Zhang H, Du H, Boivin R, Wang Y, Romo D, Littlefield BA. Kuznetsov G, et al. Among authors: littlefield ba. Mol Cancer Ther. 2009 May;8(5):1250-60. doi: 10.1158/1535-7163.MCT-08-1026. Epub 2009 May 5. Mol Cancer Ther. 2009. PMID: 19417157 Free PMC article.
Synthesis and biological evaluation of (-)-laulimalide analogues.
Gallagher BM Jr, Fang FG, Johannes CW, Pesant M, Tremblay MR, Zhao H, Akasaka K, Li XY, Liu J, Littlefield BA. Gallagher BM Jr, et al. Among authors: littlefield ba. Bioorg Med Chem Lett. 2004 Feb 9;14(3):575-9. doi: 10.1016/j.bmcl.2003.12.001. Bioorg Med Chem Lett. 2004. PMID: 14741246
Structurally simplified macrolactone analogues of halichondrin B.
Seletsky BM, Wang Y, Hawkins LD, Palme MH, Habgood GJ, DiPietro LV, Towle MJ, Salvato KA, Wels BF, Aalfs KK, Kishi Y, Littlefield BA, Yu MJ. Seletsky BM, et al. Among authors: littlefield ba. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5547-50. doi: 10.1016/j.bmcl.2004.08.068. Bioorg Med Chem Lett. 2004. PMID: 15482921
Macrocyclic ketone analogues of halichondrin B.
Zheng W, Seletsky BM, Palme MH, Lydon PJ, Singer LA, Chase CE, Lemelin CA, Shen Y, Davis H, Tremblay L, Towle MJ, Salvato KA, Wels BF, Aalfs KK, Kishi Y, Littlefield BA, Yu MJ. Zheng W, et al. Among authors: littlefield ba. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5551-4. doi: 10.1016/j.bmcl.2004.08.069. Bioorg Med Chem Lett. 2004. PMID: 15482922
In vitro and in vivo anticancer activity of (+)-spongistatin 1.
Xu Q, Huang KC, Tendyke K, Marsh J, Liu J, Qiu D, Littlefield BA, Nomoto K, Atasoylu O, Risatti CA, Sperry JB, Smith AB 3rd. Xu Q, et al. Among authors: littlefield ba. Anticancer Res. 2011 Sep;31(9):2773-9. Anticancer Res. 2011. PMID: 21868519 Free PMC article.
62 results