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Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.
Carpinelli MR, Hilton DJ, Metcalf D, Antonchuk JL, Hyland CD, Mifsud SL, Di Rago L, Hilton AA, Willson TA, Roberts AW, Ramsay RG, Nicola NA, Alexander WS. Carpinelli MR, et al. Among authors: metcalf d. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6553-8. doi: 10.1073/pnas.0401496101. Epub 2004 Apr 7. Proc Natl Acad Sci U S A. 2004. PMID: 15071178 Free PMC article.
A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.
Majewski IJ, Metcalf D, Mielke LA, Krebs DL, Ellis S, Carpinelli MR, Mifsud S, Di Rago L, Corbin J, Nicola NA, Hilton DJ, Alexander WS. Majewski IJ, et al. Among authors: metcalf d. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14146-51. doi: 10.1073/pnas.0606439103. Epub 2006 Sep 11. Proc Natl Acad Sci U S A. 2006. PMID: 16966598 Free PMC article.
Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia.
Glaser S, Metcalf D, Wu L, Hart AH, DiRago L, Mifsud S, D'Amico A, Dagger S, Campo C, Chan AC, Izon DJ, Robb L. Glaser S, et al. Among authors: d amico a, metcalf d. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16460-5. doi: 10.1073/pnas.0607776103. Epub 2006 Oct 23. Proc Natl Acad Sci U S A. 2006. PMID: 17060613 Free PMC article.
778 results