Gomez-Puertas P - Search Results

1

Computational approaches to model ligand selectivity in drug design.

Ortiz AR, Gomez-Puertas P, Leo-Macias A, Lopez-Romero P, Lopez-Viñas E, Morreale A, Murcia M, Wang K. Ortiz AR, et al. Curr Top Med Chem. 2006;6(1):41-55. doi: 10.2174/156802606775193338. Curr Top Med Chem. 2006. PMID: 16454757 Review.

2

Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.

Morillas M, López-Viñas E, Valencia A, Serra D, Gómez-Puertas P, Hegardt FG, Asins G. Morillas M, et al. Biochem J. 2004 May 1;379(Pt 3):777-84. doi: 10.1042/BJ20031373. Biochem J. 2004. PMID: 14711372 Free PMC article.

3

Redesign of carnitine acetyltransferase specificity by protein engineering.

Cordente AG, López-Viñas E, Vázquez MI, Swiegers JH, Pretorius IS, Gómez-Puertas P, Hegardt FG, Asins G, Serra D. Cordente AG, et al. J Biol Chem. 2004 Aug 6;279(32):33899-908. doi: 10.1074/jbc.M402685200. Epub 2004 May 21. J Biol Chem. 2004. PMID: 15155769 Free article.

4

Skipping of exon 2 and exons 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)8 TIM barrel model of HL.

Puisac B, López-Viñas E, Moreno S, Mir C, Pérez-Cerdá C, Menao S, Lluch D, Pié A, Gómez-Puertas P, Casals N, Ugarte M, Hegardt F, Pié J. Puisac B, et al. Biophys Chem. 2005 Apr 1;115(2-3):241-5. doi: 10.1016/j.bpc.2004.12.031. Epub 2005 Jan 6. Biophys Chem. 2005. PMID: 15752612

5

Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation.

Bentebibel A, Sebastián D, Herrero L, López-Viñas E, Serra D, Asins G, Gómez-Puertas P, Hegardt FG. Bentebibel A, et al. Biochemistry. 2006 Apr 11;45(14):4339-50. doi: 10.1021/bi052186q. Biochemistry. 2006. PMID: 16584169

6

A single-residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase.

Mir C, Lopez-Viñas E, Aledo R, Puisac B, Rizzo C, Dionisi-Vici C, Deodato F, Pié J, Gomez-Puertas P, Hegardt FG, Casals N. Mir C, et al. J Inherit Metab Dis. 2006 Feb;29(1):64-70. doi: 10.1007/s10545-006-0138-x. J Inherit Metab Dis. 2006. PMID: 16601870

7

Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase.

Cordente AG, López-Viñas E, Vázquez MI, Gómez-Puertas P, Asins G, Serra D, Hegardt FG. Cordente AG, et al. Biochemistry. 2006 May 16;45(19):6133-41. doi: 10.1021/bi0602664. Biochemistry. 2006. PMID: 16681386

8

Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A.

López-Viñas E, Bentebibel A, Gurunathan C, Morillas M, de Arriaga D, Serra D, Asins G, Hegardt FG, Gómez-Puertas P. López-Viñas E, et al. J Biol Chem. 2007 Jun 22;282(25):18212-18224. doi: 10.1074/jbc.M700885200. Epub 2007 Apr 23. J Biol Chem. 2007. PMID: 17452323 Free article.

9

C-terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity.

Carrasco P, Menao S, López-Viñas E, Santpere G, Clotet J, Sierra AY, Gratacós E, Puisac B, Gómez-Puertas P, Hegardt FG, Pie J, Casals N. Carrasco P, et al. Mol Genet Metab. 2007 Jun;91(2):120-7. doi: 10.1016/j.ymgme.2007.03.007. Epub 2007 Apr 24. Mol Genet Metab. 2007. PMID: 17459752

10

Molecular genetics of HMG-CoA lyase deficiency.

Pié J, López-Viñas E, Puisac B, Menao S, Pié A, Casale C, Ramos FJ, Hegardt FG, Gómez-Puertas P, Casals N. Pié J, et al. Mol Genet Metab. 2007 Nov;92(3):198-209. doi: 10.1016/j.ymgme.2007.06.020. Epub 2007 Aug 9. Mol Genet Metab. 2007. PMID: 17692550 Review.

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