Patane MA - Search Results

1

Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists.

Vos TJ, Balani S, Blackburn C, Chau RW, Danca MD, Drabic SV, Farrer CA, Patane MA, Stroud SG, Yowe DL, Claiborne CF. Vos TJ, et al. Among authors: patane ma. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2302-5. doi: 10.1016/j.bmcl.2006.01.016. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16458508

2

Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R).

Marsilje TH, Roses JB, Calderwood EF, Stroud SG, Forsyth NE, Blackburn C, Yowe DL, Miao W, Drabic SV, Bohane MD, Daniels JS, Li P, Wu L, Patane MA, Claiborne CF. Marsilje TH, et al. Among authors: patane ma. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3721-5. doi: 10.1016/j.bmcl.2004.05.003. Bioorg Med Chem Lett. 2004. PMID: 15203150

3

Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model.

Vos TJ, Caracoti A, Che JL, Dai M, Farrer CA, Forsyth NE, Drabic SV, Horlick RA, Lamppu D, Yowe DL, Balani S, Li P, Zeng H, Joseph IB, Rodriguez LE, Maguire MP, Patane MA, Claiborne CF. Vos TJ, et al. Among authors: patane ma. J Med Chem. 2004 Mar 25;47(7):1602-4. doi: 10.1021/jm034244g. J Med Chem. 2004. PMID: 15027849

4

Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists.

Vasudevan A, LaMarche MJ, Blackburn C, Che JL, Luchaco-Cullis CA, Lai S, Marsilje TH, Patane MA, Souers AJ, Wodka D, Geddes B, Chen S, Brodjian S, Falls DH, Dayton BD, Bush E, Brune M, Shapiro RD, Marsh KC, Hernandez LE, Sham HL, Collins CA, Kym PR. Vasudevan A, et al. Among authors: patane ma. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4174-9. doi: 10.1016/j.bmcl.2005.06.089. Bioorg Med Chem Lett. 2005. PMID: 16085414

5

Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).

Ghosh S, Elder A, Guo J, Mani U, Patane M, Carson K, Ye Q, Bennett R, Chi S, Jenkins T, Guan B, Kolbeck R, Smith S, Zhang C, LaRosa G, Jaffee B, Yang H, Eddy P, Lu C, Uttamsingh V, Horlick R, Harriman G, Flynn D. Ghosh S, et al. J Med Chem. 2006 May 4;49(9):2669-72. doi: 10.1021/jm050965z. J Med Chem. 2006. PMID: 16640325

6

Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists.

Kym PR, Iyengar R, Souers AJ, Lynch JK, Judd AS, Gao J, Freeman J, Mulhern M, Zhao G, Vasudevan A, Wodka D, Blackburn C, Brown J, Che JL, Cullis C, Lai SJ, LaMarche MJ, Marsilje T, Roses J, Sells T, Geddes B, Govek E, Patane M, Fry D, Dayton BD, Brodjian S, Falls D, Brune M, Bush E, Shapiro R, Knourek-Segel V, Fey T, McDowell C, Reinhart GA, Preusser LC, Marsh K, Hernandez L, Sham HL, Collins CA. Kym PR, et al. J Med Chem. 2005 Sep 22;48(19):5888-91. doi: 10.1021/jm050598r. J Med Chem. 2005. PMID: 16161992

7

Phenylacetamides as selective alpha-1A adrenergic receptor antagonists.

Patane MA, DiPardo RM, Newton RC, Price RP, Broten TP, Chang RS, Ransom RW, Di Salvo J, Nagarathnam D, Forray C, Gluchowski C, Bock MG. Patane MA, et al. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1621-4. doi: 10.1016/s0960-894x(00)00307-3. Bioorg Med Chem Lett. 2000. PMID: 10937709

8

Addressing hERG activity while maintaining favorable potency, selectivity and pharmacokinetic properties of PPARδ modulators.

Lagu B, Senaiar RS, Kluge AF, Mallesh B, Ramakrishna M, Bhat R, Patane MA. Lagu B, et al. Among authors: patane ma. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126928. doi: 10.1016/j.bmcl.2019.126928. Epub 2019 Dec 23. Bioorg Med Chem Lett. 2020. PMID: 31889664

9

Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity.

Patane MA, DiPardo RM, Price RP, Chang RS, Ransom RW, O'Malley SS, Di Salvo J, Bock MG. Patane MA, et al. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2495-500. doi: 10.1016/s0960-894x(98)00451-x. Bioorg Med Chem Lett. 1998. PMID: 9873568

10

Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516.

Lagu B, Kluge AF, Goddeeris MM, Tozzo E, Fredenburg RA, Chellur S, Senaiar RS, Jaleel M, Babu DRK, Tiwari NK, Takahashi T, Patane MA. Lagu B, et al. Among authors: patane ma. Bioorg Med Chem Lett. 2018 Feb 1;28(3):533-536. doi: 10.1016/j.bmcl.2017.11.006. Epub 2017 Nov 4. Bioorg Med Chem Lett. 2018. PMID: 29275935

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