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Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors.
Bioorg Med Chem Lett. 2006 Apr 15;16(8):2076-80. doi: 10.1016/j.bmcl.2006.01.059. Epub 2006 Feb 7.
Bioorg Med Chem Lett. 2006.
PMID: 16464588
The steady-state pharmacokinetics and bioequivalence of carprofen administered orally and subcutaneously in dogs.
Clark TP, Chieffo C, Huhn JC, Nimz EL, Wang C, Boy MG.
Clark TP, et al. Among authors: nimz el.
J Vet Pharmacol Ther. 2003 Jun;26(3):187-92. doi: 10.1046/j.1365-2885.2003.00475.x.
J Vet Pharmacol Ther. 2003.
PMID: 12755902
Clinical Trial.
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Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine.
Li J, DeMello KM, Cheng H, Sakya SM, Bronk BS, Rafka RJ, Jaynes BH, Ziegler CB, Kilroy C, Mann DW, Nimz EL, Lynch MP, Haven ML, Kolosko NL, Minich ML, Li C, Dutra JK, Rast B, Crosson RM, Morton BJ, Kirk GW, Callaghan KM, Koss DA, Shavnya A, Lund LA, Seibel SB, Petras CF, Silvia A.
Li J, et al. Among authors: nimz el.
Bioorg Med Chem Lett. 2004 Jan 5;14(1):95-8. doi: 10.1016/j.bmcl.2003.10.004.
Bioorg Med Chem Lett. 2004.
PMID: 14684306
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