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Page 1
Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.
Beevers RE, Buckley GM, Davies N, Fraser JL, Galvin FC, Hannah DR, Haughan AF, Jenkins K, Mack SR, Pitt WR, Ratcliffe AJ, Richard MD, Sabin V, Sharpe A, Williams SC. Beevers RE, et al. Among authors: buckley gm. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. doi: 10.1016/j.bmcl.2006.01.090. Epub 2006 Feb 17. Bioorg Med Chem Lett. 2006. PMID: 16483773
Optimization of a series of multi-isoform PI3 kinase inhibitors.
Perry B, Beevers R, Bennett G, Buckley G, Crabbe T, Gowers L, James L, Jenkins K, Lock C, Sabin V, Wright S. Perry B, et al. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5299-302. doi: 10.1016/j.bmcl.2008.08.042. Epub 2008 Aug 20. Bioorg Med Chem Lett. 2008. PMID: 18774713
Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.
Buckley GM, Davies N, Dyke HJ, Gilbert PJ, Hannah DR, Haughan AF, Hunt CA, Pitt WR, Profit RH, Ray NC, Richard MD, Sharpe A, Taylor AJ, Whitworth JM, Williams SC. Buckley GM, et al. Bioorg Med Chem Lett. 2005 Feb 1;15(3):751-4. doi: 10.1016/j.bmcl.2004.11.015. Bioorg Med Chem Lett. 2005. PMID: 15664851
Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.
Birch HL, Buckley GM, Davies N, Dyke HJ, Frost EJ, Gilbert PJ, Hannah DR, Haughan AF, Madigan MJ, Morgan T, Pitt WR, Ratcliffe AJ, Ray NC, Richard MD, Sharpe A, Taylor AJ, Whitworth JM, Williams SC. Birch HL, et al. Among authors: buckley gm. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5335-9. doi: 10.1016/j.bmcl.2005.06.108. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16202581
Low molecular weight indole fragments as IMPDH inhibitors.
Beevers RE, Buckley GM, Davies N, Fraser JL, Galvin FC, Hannah DR, Haughan AF, Jenkins K, Mack SR, Pitt WR, Ratcliffe AJ, Richard MD, Sabin V, Sharpe A, Williams SC. Beevers RE, et al. Among authors: buckley gm. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. doi: 10.1016/j.bmcl.2006.01.089. Epub 2006 Feb 17. Bioorg Med Chem Lett. 2006. PMID: 16483769
IRAK-4 inhibitors. Part 1: a series of amides.
Buckley GM, Gowers L, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V, Fraser JL. Buckley GM, et al. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3211-4. doi: 10.1016/j.bmcl.2008.04.058. Epub 2008 Apr 26. Bioorg Med Chem Lett. 2008. PMID: 18474425
IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.
Buckley GM, Fosbeary R, Fraser JL, Gowers L, Higueruelo AP, James LA, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V. Buckley GM, et al. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3656-60. doi: 10.1016/j.bmcl.2008.04.042. Epub 2008 Apr 24. Bioorg Med Chem Lett. 2008. PMID: 18501603
7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.
Buckley G, Cooper N, Dyke HJ, Galleway F, Gowers L, Gregory JC, Hannah DR, Haughan AF, Hellewell PG, Kendall HJ, Lowe C, Maxey R, Montana JG, Naylor R, Picken CL, Runcie KA, Sabin V, Tuladhar BR, Warneck JB. Buckley G, et al. Bioorg Med Chem Lett. 2000 Sep 18;10(18):2137-40. doi: 10.1016/s0960-894x(00)00426-1. Bioorg Med Chem Lett. 2000. PMID: 10999488
18 results