Tokunaga T - Search Results

1

Enhanced effect of combined treatment with SMP-534 (antifibrotic agent) and losartan in diabetic nephropathy.

Sugaru E, Nakagawa T, Ono-Kishino M, Nagamine J, Tokunaga T, Kitoh M, Hume WE, Nagata R, Taiji M. Sugaru E, et al. Among authors: tokunaga t. Am J Nephrol. 2006;26(1):50-8. doi: 10.1159/000091786. Epub 2006 Feb 24. Am J Nephrol. 2006. PMID: 16508247

2

SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice.

Sugaru E, Nakagawa T, Ono-Kishino M, Nagamine J, Tokunaga T, Kitoh M, Hume WE, Nagata R, Taiji M. Sugaru E, et al. Among authors: tokunaga t. Am J Physiol Renal Physiol. 2006 Apr;290(4):F813-20. doi: 10.1152/ajprenal.00357.2005. Epub 2005 Nov 8. Am J Physiol Renal Physiol. 2006. PMID: 16278277 Free article.

3

Amelioration of established diabetic nephropathy by combined treatment with SMP-534 (antifibrotic agent) and losartan in db/db mice.

Sugaru E, Nakagawa T, Ono-Kishino M, Nagamine J, Tokunaga T, Kitoh M, Hume WE, Nagata R, Taiji M. Sugaru E, et al. Among authors: tokunaga t. Nephron Exp Nephrol. 2007;105(2):e45-52. doi: 10.1159/000097603. Epub 2006 Nov 30. Nephron Exp Nephrol. 2007. PMID: 17139189

4

Chronic administration of SMP-534 ameliorates renal dysfunction in 5/6 nephrectomized rats.

Tsujimura T, Nagamine J, Sugaru E, Nakagawa T, Ono-Kishino M, Tokunaga T, Kitoh M, Nagata R, Taiji M. Tsujimura T, et al. Among authors: tokunaga t. Nephron Exp Nephrol. 2008;110(4):e99-108. doi: 10.1159/000167795. Epub 2008 Oct 30. Nephron Exp Nephrol. 2008. PMID: 18971587

5

The anti-fibrotic agent SMP-534 attenuates bleomycin-induced pulmonary fibrosis in hamsters.

Tsujimura T, Ono-Kishino M, Nagamine J, Sugaru E, Tokunaga T, Kitoh M, Nagata R, Nakagawa T, Taiji M. Tsujimura T, et al. Among authors: tokunaga t. Biomed Res. 2009 Jun;30(3):177-82. doi: 10.2220/biomedres.30.177. Biomed Res. 2009. PMID: 19574719 Free article.

6

Combination therapy with SMP-534 and an angiotensin-converting enzyme inhibitor provides additional renoprotection in 5/6 nephrectomized rats.

Tsujimura T, Nagamine J, Sugaru E, Ono-Kishino M, Tokunaga T, Kitoh M, Nagata R, Nakagawa T, Taiji M. Tsujimura T, et al. Among authors: tokunaga t. Biol Pharm Bull. 2009 Dec;32(12):1991-6. doi: 10.1248/bpb.32.1991. Biol Pharm Bull. 2009. PMID: 19952417 Free article.

7

SMP-534 inhibits TGF-beta-induced ECM production in fibroblast cells and reduces mesangial matrix accumulation in experimental glomerulonephritis.

Sugaru E, Sakai M, Horigome K, Tokunaga T, Kitoh M, Hume WE, Nagata R, Nakagawa T, Taiji M. Sugaru E, et al. Among authors: tokunaga t. Am J Physiol Renal Physiol. 2005 Nov;289(5):F998-1004. doi: 10.1152/ajprenal.00065.2005. Epub 2005 May 17. Am J Physiol Renal Physiol. 2005. PMID: 15900023 Free article.

8

Synthesis and pharmacological profile of an orally-active growth hormone secretagogue, SM-130686.

Nagamine J, Kawamura T, Tokunaga T, Hume WE, Nagata R, Nakagawa T, Taiji M. Nagamine J, et al. Among authors: tokunaga t. Comb Chem High Throughput Screen. 2006 Mar;9(3):187-96. doi: 10.2174/138620706776055548. Comb Chem High Throughput Screen. 2006. PMID: 16533152 Review.

9

Structure-activity relationships of the oxindole growth hormone secretagogues.

Tokunaga T, Hume WE, Nagamine J, Kawamura T, Taiji M, Nagata R. Tokunaga T, et al. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1789-92. doi: 10.1016/j.bmcl.2005.02.042. Bioorg Med Chem Lett. 2005. PMID: 15780607

10

Oxindole derivatives as orally active potent growth hormone secretagogues.

Tokunaga T, Hume WE, Umezome T, Okazaki K, Ueki Y, Kumagai K, Hourai S, Nagamine J, Seki H, Taiji M, Noguchi H, Nagata R. Tokunaga T, et al. J Med Chem. 2001 Dec 20;44(26):4641-9. doi: 10.1021/jm0103763. J Med Chem. 2001. PMID: 11741481

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