Sohma Y - Search Results

1

O-N intramolecular alkoxycarbonyl migration of typical protective groups in hydroxyamino acids.

Skwarczynski M, Sohma Y, Noguchi M, Kimura T, Hayashi Y, Kiso Y. Skwarczynski M, et al. Among authors: sohma y. J Org Chem. 2006 Mar 17;71(6):2542-5. doi: 10.1021/jo0525579. J Org Chem. 2006. PMID: 16526815

2

New water-soluble prodrugs of HIV protease inhibitors based on O-->N intramolecular acyl migration.

Hamada Y, Ohtake J, Sohma Y, Kimura T, Hayashi Y, Kiso Y. Hamada Y, et al. Among authors: sohma y. Bioorg Med Chem. 2002 Dec;10(12):4155-67. doi: 10.1016/s0968-0896(02)00322-x. Bioorg Med Chem. 2002. PMID: 12413869

3

A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: design and synthesis of isotaxel.

Hayashi Y, Skwarczynski M, Hamada Y, Sohma Y, Kimura T, Kiso Y. Hayashi Y, et al. Among authors: sohma y. J Med Chem. 2003 Aug 28;46(18):3782-4. doi: 10.1021/jm034112n. J Med Chem. 2003. PMID: 12930140

4

Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage.

Sohma Y, Hayashi Y, Ito T, Matsumoto H, Kimura T, Kiso Y. Sohma Y, et al. J Med Chem. 2003 Sep 11;46(19):4124-35. doi: 10.1021/jm030009m. J Med Chem. 2003. PMID: 12954064

5

O-N intramolecular acyl migration strategy in water-soluble prodrugs of taxoids.

Skwarczynski M, Sohma Y, Kimura M, Hayashi Y, Kimura T, Kiso Y. Skwarczynski M, et al. Among authors: sohma y. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4441-4. doi: 10.1016/j.bmcl.2003.09.020. Bioorg Med Chem Lett. 2003. PMID: 14643342

6

Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl isopeptides.

Sohma Y, Sasaki M, Hayashi Y, Kimura T, Kiso Y. Sohma Y, et al. Chem Commun (Camb). 2004 Jan 7;(1):124-5. doi: 10.1039/b312129a. Epub 2003 Nov 21. Chem Commun (Camb). 2004. PMID: 14737363

7

O-N intramolecular acyl migration reaction in the development of prodrugs and the synthesis of difficult sequence-containing bioactive peptides.

Sohma Y, Hayashi Y, Skwarczynski M, Hamada Y, Sasaki M, Kimura T, Kiso Y. Sohma Y, et al. Biopolymers. 2004;76(4):344-56. doi: 10.1002/bip.20136. Biopolymers. 2004. PMID: 15386265

8

The 'O-acyl isopeptide method' for the synthesis of difficult sequence-containing peptides: application to the synthesis of Alzheimer's disease-related amyloid beta peptide (Abeta) 1-42.

Sohma Y, Hayashi Y, Kimura M, Chiyomori Y, Taniguchi A, Sasaki M, Kimura T, Kiso Y. Sohma Y, et al. J Pept Sci. 2005 Jul;11(8):441-51. doi: 10.1002/psc.649. J Pept Sci. 2005. PMID: 15761877

9

No auxiliary, no byproduct strategy for water-soluble prodrugs of taxoids: scope and limitation of O-N intramolecular acyl and acyloxy migration reactions.

Skwarczynski M, Sohma Y, Noguchi M, Kimura M, Hayashi Y, Hamada Y, Kimura T, Kiso Y. Skwarczynski M, et al. Among authors: sohma y. J Med Chem. 2005 Apr 7;48(7):2655-66. doi: 10.1021/jm049344g. J Med Chem. 2005. PMID: 15801856

10

'O-Acyl isopeptide method' for the efficient preparation of amyloid beta peptide 1-42 mutants.

Sohma Y, Chiyomori Y, Kimura M, Fukao F, Taniguchi A, Hayashi Y, Kimura T, Kiso Y. Sohma Y, et al. Bioorg Med Chem. 2005 Nov 15;13(22):6167-74. doi: 10.1016/j.bmc.2005.06.037. Bioorg Med Chem. 2005. PMID: 16040249

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