McElhinney RS - Search Results

1

Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors.

Ranson M, Middleton MR, Bridgewater J, Lee SM, Dawson M, Jowle D, Halbert G, Waller S, McGrath H, Gumbrell L, McElhinney RS, Donnelly D, McMurry TB, Margison GP. Ranson M, et al. Among authors: mcelhinney rs. Clin Cancer Res. 2006 Mar 1;12(5):1577-84. doi: 10.1158/1078-0432.CCR-05-2198. Clin Cancer Res. 2006. PMID: 16533784 Clinical Trial.

2

Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain.

McElhinney RS, Donnelly DJ, McCormick JE, Kelly J, Watson AJ, Rafferty JA, Elder RH, Middleton MR, Willington MA, McMurry TB, Margison GP. McElhinney RS, et al. J Med Chem. 1998 Dec 17;41(26):5265-71. doi: 10.1021/jm9708644. J Med Chem. 1998. PMID: 9857094

3

Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice.

Bibby MC, Thompson MJ, Rafferty JA, Margison GP, McElhinney RS. Bibby MC, et al. Among authors: mcelhinney rs. Br J Cancer. 1999 Mar;79(9-10):1332-9. doi: 10.1038/sj.bjc.6690215. Br J Cancer. 1999. PMID: 10188873 Free PMC article.

4

O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts.

Middleton MR, Kelly J, Thatcher N, Donnelly DJ, McElhinney RS, McMurry TB, McCormick JE, Margison GP. Middleton MR, et al. Among authors: mcelhinney rs. Int J Cancer. 2000 Jan 15;85(2):248-52. doi: 10.1002/(sici)1097-0215(20000115)85:2<248::aid-ijc16>3.0.co;2-v. Int J Cancer. 2000. PMID: 10629085

5

Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model.

Middleton MR, Thatcher N, McMurry TB, McElhinney RS, Donnelly DJ, Margison GP. Middleton MR, et al. Among authors: mcelhinney rs. Int J Cancer. 2002 Aug 10;100(5):615-7. doi: 10.1002/ijc.10532. Int J Cancer. 2002. PMID: 12124813

6

O6-alkylguanine-DNA alkyltransferase inactivation in cancer chemotherapy.

McElhinney RS, McMurry TB, Margison GP. McElhinney RS, et al. Mini Rev Med Chem. 2003 Aug;3(5):471-85. doi: 10.2174/1389557033487980. Mini Rev Med Chem. 2003. PMID: 12769698 Review.

7

Dual repair modulation reverses Temozolomide resistance in vitro.

Barvaux VA, Ranson M, Brown R, McElhinney RS, McMurry TB, Margison GP. Barvaux VA, et al. Among authors: mcelhinney rs. Mol Cancer Ther. 2004 Feb;3(2):123-7. Mol Cancer Ther. 2004. PMID: 14985452

8

Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase.

Barvaux VA, Lorigan P, Ranson M, Gillum AM, McElhinney RS, McMurry TB, Margison GP. Barvaux VA, et al. Among authors: mcelhinney rs. Mol Cancer Ther. 2004 Oct;3(10):1215-20. Mol Cancer Ther. 2004. PMID: 15486188

9

O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts.

Clemons M, Kelly J, Watson AJ, Howell A, McElhinney RS, McMurry TB, Margison GP. Clemons M, et al. Among authors: mcelhinney rs. Br J Cancer. 2005 Nov 14;93(10):1152-6. doi: 10.1038/sj.bjc.6602833. Br J Cancer. 2005. PMID: 16278661 Free PMC article.

10

Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT).

Shibata T, Glynn N, McMurry TB, McElhinney RS, Margison GP, Williams DM. Shibata T, et al. Among authors: mcelhinney rs. Nucleic Acids Res. 2006 Apr 11;34(6):1884-91. doi: 10.1093/nar/gkl117. Print 2006. Nucleic Acids Res. 2006. PMID: 16609128 Free PMC article.

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