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Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype.
Walker MA, Johnson T, Ma Z, Zhang Y, Banville J, Remillard R, Plamondon S, Pendri A, Wong H, Smith D, Torri A, Samanta H, Lin Z, Deminie C, Terry B, Krystal M, Meanwell N. Walker MA, et al. Among authors: johnson t. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5818-21. doi: 10.1016/j.bmcl.2006.08.075. Epub 2006 Sep 12. Bioorg Med Chem Lett. 2006. PMID: 16971121
Benzyl amide-ketoacid inhibitors of HIV-integrase.
Walker MA, Johnson T, Naidu BN, Banville J, Remillard R, Plamondon S, Martel A, Li C, Torri A, Samanta H, Lin Z, Dicker I, Krystal M, Meanwell NA. Walker MA, et al. Among authors: johnson t. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4886-90. doi: 10.1016/j.bmcl.2007.06.042. Epub 2007 Jun 14. Bioorg Med Chem Lett. 2007. PMID: 17604626
Synthesis of a novel C-10 spiro-epoxide of paclitaxel.
Walker MA, Johnson TD, Huang S, Vyas DM, Kadow JF. Walker MA, et al. Among authors: johnson td. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1683-5. doi: 10.1016/s0960-894x(01)00280-3. Bioorg Med Chem Lett. 2001. PMID: 11425537
Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947.
Brockunier L, Stelmach J, Guo J, Spencer T, Rosauer K, Bansal A, Cai SJ, Chen N, Cummings J, Huang L, Johnson T, Levesque S, Luo L, Maloney K, Metzger J, Mortko C, Ortega K, Pai LY, Pereira A, Salituro G, Shang J, Shepherd C, Sherrie Xu S, Yang Q, Cui J, Roy S, Parmee E, Raghavan S. Brockunier L, et al. Among authors: johnson t. Bioorg Med Chem Lett. 2020 Nov 1;30(21):127574. doi: 10.1016/j.bmcl.2020.127574. Epub 2020 Sep 24. Bioorg Med Chem Lett. 2020. PMID: 32980512
Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.
Kindon N, Andrews G, Baxter A, Cheshire D, Hemsley P, Johnson T, Liu YZ, McGinnity D, McHale M, Mete A, Reuberson J, Roberts B, Steele J, Teobald B, Unitt J, Vaughan D, Walters I, Stocks MJ. Kindon N, et al. Among authors: johnson t. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986. doi: 10.1021/acsmedchemlett.7b00315. eCollection 2017 Sep 14. ACS Med Chem Lett. 2017. PMID: 28947948 Free PMC article.
Transcription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers.
Fettweis G, Wagh K, Stavreva DA, Jiménez-Panizo A, Kim S, Lion M, Alegre-Martí A, Johnson TA, Ball DA, Karpova TS, Upadhyaya A, Vertommen D, Recio JF, Estébanez-Perpiñá E, Dequiedt F, Hager GL. Fettweis G, et al. Among authors: johnson ta. bioRxiv [Preprint]. 2024 Dec 9:2024.12.09.627537. doi: 10.1101/2024.12.09.627537. bioRxiv. 2024. PMID: 39713324 Free PMC article. Preprint.
6,946 results