Feldman PL - Search Results

1

Opioid receptor activity of GI 87084B, a novel ultra-short acting analgesic, in isolated tissues.

James MK, Feldman PL, Schuster SV, Bilotta JM, Brackeen MF, Leighton HJ. James MK, et al. Among authors: feldman pl. J Pharmacol Exp Ther. 1991 Nov;259(2):712-8. J Pharmacol Exp Ther. 1991. PMID: 1658308

2

Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgetics.

Feldman PL, James MK, Brackeen MF, Bilotta JM, Schuster SV, Lahey AP, Lutz MW, Johnson MR, Leighton HJ. Feldman PL, et al. J Med Chem. 1991 Jul;34(7):2202-8. doi: 10.1021/jm00111a041. J Med Chem. 1991. PMID: 2066993

3

A pharmacodynamic model to investigate the structure-activity profile of a series of novel opioid analgesics.

Lutz MW, Morgan PH, James MK, Feldman PL, Brackeen MF, Lahey AP, James SV, Bilotta JM, Pressley JC. Lutz MW, et al. Among authors: feldman pl. J Pharmacol Exp Ther. 1994 Nov;271(2):795-803. J Pharmacol Exp Ther. 1994. PMID: 7965798

4

Phosphodiesterase type IV inhibition. Structure-activity relationships of 1,3-disubstituted pyrrolidines.

Feldman PL, Brackeen MF, Cowan DJ, Marron BE, Schoenen FJ, Stafford JA, Suh EM, Domanico PL, Rose D, Leesnitzer MA, et al. Feldman PL, et al. J Med Chem. 1995 Apr 28;38(9):1505-10. doi: 10.1021/jm00009a011. J Med Chem. 1995. PMID: 7739009

5

Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase.

Brackeen MF, Cowan DJ, Stafford JA, Schoenen FJ, Veal JM, Domanico PL, Rose D, Strickland AB, Verghese M, Feldman PL. Brackeen MF, et al. Among authors: feldman pl. J Med Chem. 1995 Nov 24;38(24):4848-54. doi: 10.1021/jm00024a012. J Med Chem. 1995. PMID: 7490734

6

Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of (R*,R*)-(+/-)-methyl 3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3-methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase.

Stafford JA, Veal JM, Feldman PL, Valvano NL, Baer PG, Brackeen MF, Brawley ES, Connolly KM, Domanico PL, Han B, et al. Stafford JA, et al. Among authors: feldman pl. J Med Chem. 1995 Dec 22;38(26):4972-5. doi: 10.1021/jm00026a003. J Med Chem. 1995. PMID: 8544172 No abstract available.

7

Insights into the Chemical Discovery of Remifentanil.

Feldman PL. Feldman PL. Anesthesiology. 2020 May;132(5):1229-1234. doi: 10.1097/ALN.0000000000003170. Anesthesiology. 2020. PMID: 32028373 Review.

8

Bis- and mixed-tetrahydroisoquinolinium chlorofumarates: new ultra-short-acting nondepolarizing neuromuscular blockers.

Boros EE, Bigham EC, Boswell GE, Mook RA Jr, Patel SS, Savarese JJ, Ray JA, Thompson JB, Hashim MA, Wisowaty JC, Feldman PL, Samano V. Boros EE, et al. Among authors: feldman pl. J Med Chem. 1999 Jan 28;42(2):206-9. doi: 10.1021/jm980597h. J Med Chem. 1999. PMID: 9925724 No abstract available.

9

Synthesis of ultra-short-acting neuromuscular blocker GW 0430: a remarkably stereo- and regioselective synthesis of mixed tetrahydroisoquinolinium chlorofumarates.

Samano V, Ray JA, Thompson JB, Mook RA Jr, Jung DK, Koble CS, Martin MT, Bigham EC, Regitz CS, Feldman PL, Boros EE. Samano V, et al. Among authors: feldman pl. Org Lett. 1999 Dec 16;1(12):1993-6. doi: 10.1021/ol9911573. Org Lett. 1999. PMID: 10836056

10

Dual inhibition of human type 4 phosphodiesterase isostates by (R, R)-(+/-)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate.

Tian G, Rocque WJ, Wiseman JS, Thompson IZ, Holmes WD, Domanico PL, Stafford JA, Feldman PL, Luther MA. Tian G, et al. Among authors: feldman pl. Biochemistry. 1998 May 12;37(19):6894-904. doi: 10.1021/bi972700v. Biochemistry. 1998. PMID: 9578576

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