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Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.
Chou AP, Maidment N, Klintenberg R, Casida JE, Li S, Fitzmaurice AG, Fernagut PO, Mortazavi F, Chesselet MF, Bronstein JM. Chou AP, et al. Among authors: li s. J Biol Chem. 2008 Dec 12;283(50):34696-703. doi: 10.1074/jbc.M802210200. Epub 2008 Sep 25. J Biol Chem. 2008. PMID: 18818210 Free PMC article.
Mechanisms of rotenone-induced proteasome inhibition.
Chou AP, Li S, Fitzmaurice AG, Bronstein JM. Chou AP, et al. Among authors: li s. Neurotoxicology. 2010 Aug;31(4):367-72. doi: 10.1016/j.neuro.2010.04.006. Epub 2010 Apr 22. Neurotoxicology. 2010. PMID: 20417232 Free PMC article.
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