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TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P. Chen F, et al. Among authors: sanjo n. Nature. 2006 Apr 27;440(7088):1208-12. doi: 10.1038/nature04667. Nature. 2006. PMID: 16641999
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P. Chen F, et al. Among authors: sanjo n. J Biol Chem. 2003 May 30;278(22):19974-9. doi: 10.1074/jbc.M210049200. Epub 2003 Mar 18. J Biol Chem. 2003. PMID: 12646573 Free article.
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.
Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A, Kawarai T, Katayama T, Schmidt SD, Mathews PM, Schmitt-Ulms G, Fraser PE, St George-Hyslop P. Hasegawa H, et al. Among authors: sanjo n. J Biol Chem. 2004 Nov 5;279(45):46455-63. doi: 10.1074/jbc.M406289200. Epub 2004 Aug 17. J Biol Chem. 2004. PMID: 15322109 Free article.
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations.
Petit A, Kawarai T, Paitel E, Sanjo N, Maj M, Scheid M, Chen F, Gu Y, Hasegawa H, Salehi-Rad S, Wang L, Rogaeva E, Fraser P, Robinson B, St George-Hyslop P, Tandon A. Petit A, et al. Among authors: sanjo n. J Biol Chem. 2005 Oct 7;280(40):34025-32. doi: 10.1074/jbc.M505143200. Epub 2005 Aug 2. J Biol Chem. 2005. PMID: 16079129 Free article.
100 results