Wright RA - Search Results

1

Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo.

Weiss B, Alt A, Ogden AM, Gates M, Dieckman DK, Clemens-Smith A, Ho KH, Jarvie K, Rizkalla G, Wright RA, Calligaro DO, Schoepp D, Mattiuz EL, Stratford RE, Johnson B, Salhoff C, Katofiasc M, Phebus LA, Schenck K, Cohen M, Filla SA, Ornstein PL, Johnson KW, Bleakman D. Weiss B, et al. Among authors: wright ra. J Pharmacol Exp Ther. 2006 Aug;318(2):772-81. doi: 10.1124/jpet.106.101428. Epub 2006 May 11. J Pharmacol Exp Ther. 2006. PMID: 16690725

2

Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039).

Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, Nisenbaum ES, Catlow JT, Kingston AE, Giera DD, Herin MF, Monn JA, McKinzie DL, Schoepp DD. Rorick-Kehn LM, et al. Among authors: wright ra. J Pharmacol Exp Ther. 2007 Apr;321(1):308-17. doi: 10.1124/jpet.106.110809. Epub 2007 Jan 4. J Pharmacol Exp Ther. 2007. PMID: 17204749

3

In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid.

Schoepp DD, Lodge D, Bleakman D, Leander JD, Tizzano JP, Wright RA, Palmer AJ, Salhoff CR, Ornstein PL. Schoepp DD, et al. Among authors: wright ra. Neuropharmacology. 1995 Sep;34(9):1159-68. doi: 10.1016/0028-3908(95)00099-r. Neuropharmacology. 1995. PMID: 8532186

4

[3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain.

Wright RA, Arnold MB, Wheeler WJ, Ornstein PL, Schoepp DD. Wright RA, et al. J Pharmacol Exp Ther. 2001 Aug;298(2):453-60. J Pharmacol Exp Ther. 2001. PMID: 11454905

5

Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats.

Clark M, Johnson BG, Wright RA, Monn JA, Schoepp DD. Clark M, et al. Among authors: wright ra. Pharmacol Biochem Behav. 2002 Sep;73(2):339-46. doi: 10.1016/s0091-3057(02)00848-1. Pharmacol Biochem Behav. 2002. PMID: 12117588

6

Synthesis and structure-activity relationship studies of novel 2-diarylethyl substituted (2-carboxycycloprop-1-yl)glycines as high-affinity group II metabotropic glutamate receptor ligands.

Sørensen US, Bleisch TJ, Kingston AE, Wright RA, Johnson BG, Schoepp DD, Ornstein PL. Sørensen US, et al. Among authors: wright ra. Bioorg Med Chem. 2003 Jan 17;11(2):197-205. doi: 10.1016/s0968-0896(02)00387-5. Bioorg Med Chem. 2003. PMID: 12470714

7

Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus.

Wright RA, Schoepp DD. Wright RA, et al. Eur J Pharmacol. 1996 Feb 22;297(3):275-82. doi: 10.1016/0014-2999(95)00747-4. Eur J Pharmacol. 1996. PMID: 8666060

8

2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution.

Ornstein PL, Bleisch TJ, Arnold MB, Wright RA, Johnson BG, Schoepp DD. Ornstein PL, et al. Among authors: wright ra. J Med Chem. 1998 Jan 29;41(3):346-57. doi: 10.1021/jm970497w. J Med Chem. 1998. PMID: 9464366

9

2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.

Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH, Wright RA, Johnson BG, Tizzano JP, Helton DR, Kallman MJ, Schoepp DD, Hérin M. Ornstein PL, et al. Among authors: wright ra. J Med Chem. 1998 Jan 29;41(3):358-78. doi: 10.1021/jm970498o. J Med Chem. 1998. PMID: 9464367

10

Potent, stereoselective, and brain region selective modulation of second messengers in the rat brain by (+)LY354740, a novel group II metabotropic glutamate receptor agonist.

Schoepp DD, Johnson BG, Wright RA, Salhoff CR, Monn JA. Schoepp DD, et al. Among authors: wright ra. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug;358(2):175-80. doi: 10.1007/pl00005240. Naunyn Schmiedebergs Arch Pharmacol. 1998. PMID: 9750002

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