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Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).
Cox LE, Ferraiuolo L, Goodall EF, Heath PR, Higginbottom A, Mortiboys H, Hollinger HC, Hartley JA, Brockington A, Burness CE, Morrison KE, Wharton SB, Grierson AJ, Ince PG, Kirby J, Shaw PJ. Cox LE, et al. Among authors: higginbottom a. PLoS One. 2010 Mar 24;5(3):e9872. doi: 10.1371/journal.pone.0009872. PLoS One. 2010. PMID: 20352044 Free PMC article.
S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis.
Mead RJ, Higginbottom A, Allen SP, Kirby J, Bennett E, Barber SC, Heath PR, Coluccia A, Patel N, Gardner I, Brancale A, Grierson AJ, Shaw PJ. Mead RJ, et al. Among authors: higginbottom a. Free Radic Biol Med. 2013 Aug;61:438-52. doi: 10.1016/j.freeradbiomed.2013.04.018. Epub 2013 Apr 19. Free Radic Biol Med. 2013. PMID: 23608463 Free PMC article.
C9ORF72 transcription in a frontotemporal dementia case with two expanded alleles.
Cooper-Knock J, Higginbottom A, Connor-Robson N, Bayatti N, Bury JJ, Kirby J, Ninkina N, Buchman VL, Shaw PJ. Cooper-Knock J, et al. Among authors: higginbottom a. Neurology. 2013 Nov 5;81(19):1719-21. doi: 10.1212/01.wnl.0000435295.41974.2e. Epub 2013 Oct 9. Neurology. 2013. PMID: 24107864 Free PMC article.
65 results