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Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies.
Bresson D, Pugnière M, Roquet F, Rebuffat SA, N-Guyen B, Cerutti M, Guo J, McLachlan SM, Rapoport B, Estienne V, Ruf J, Chardès T, Péraldi-Roux S. Bresson D, et al. Among authors: guo j. J Biol Chem. 2004 Sep 10;279(37):39058-67. doi: 10.1074/jbc.M403897200. Epub 2004 May 18. J Biol Chem. 2004. PMID: 15150267 Free article.
Human thyroperoxidase folds in one complex B-cell immunodominant region.
Blanchin S, Estienne V, Guo J, Rapoport B, McLachlan SM, Carayon P, Ruf J. Blanchin S, et al. Among authors: guo j. Biochem Biophys Res Commun. 2002 Aug 2;295(5):1118-24. doi: 10.1016/s0006-291x(02)00827-6. Biochem Biophys Res Commun. 2002. PMID: 12135610
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