Qin D - Search Results

1

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

Ding K, Lu Y, Nikolovska-Coleska Z, Wang G, Qiu S, Shangary S, Gao W, Qin D, Stuckey J, Krajewski K, Roller PP, Wang S. Ding K, et al. Among authors: qin d. J Med Chem. 2006 Jun 15;49(12):3432-5. doi: 10.1021/jm051122a. J Med Chem. 2006. PMID: 16759082

2

Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.

Lu Y, Nikolovska-Coleska Z, Fang X, Gao W, Shangary S, Qiu S, Qin D, Wang S. Lu Y, et al. Among authors: qin d. J Med Chem. 2006 Jun 29;49(13):3759-62. doi: 10.1021/jm060023+. J Med Chem. 2006. PMID: 16789731

3

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition.

Shangary S, Qin D, McEachern D, Liu M, Miller RS, Qiu S, Nikolovska-Coleska Z, Ding K, Wang G, Chen J, Bernard D, Zhang J, Lu Y, Gu Q, Shah RB, Pienta KJ, Ling X, Kang S, Guo M, Sun Y, Yang D, Wang S. Shangary S, et al. Among authors: qin d. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3933-8. doi: 10.1073/pnas.0708917105. Epub 2008 Mar 3. Proc Natl Acad Sci U S A. 2008. PMID: 18316739 Free PMC article.

4

Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP).

Sun H, Stuckey JA, Nikolovska-Coleska Z, Qin D, Meagher JL, Qiu S, Lu J, Yang CY, Saito NG, Wang S. Sun H, et al. Among authors: qin d. J Med Chem. 2008 Nov 27;51(22):7169-80. doi: 10.1021/jm8006849. J Med Chem. 2008. PMID: 18954041 Free PMC article.

5

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction.

Yu S, Qin D, Shangary S, Chen J, Wang G, Ding K, McEachern D, Qiu S, Nikolovska-Coleska Z, Miller R, Kang S, Yang D, Wang S. Yu S, et al. Among authors: qin d. J Med Chem. 2009 Dec 24;52(24):7970-3. doi: 10.1021/jm901400z. J Med Chem. 2009. PMID: 19928922 Free PMC article.

6

Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases.

Sun W, Nikolovska-Coleska Z, Qin D, Sun H, Yang CY, Bai L, Qiu S, Wang Y, Ma D, Wang S. Sun W, et al. Among authors: qin d. J Med Chem. 2009 Feb 12;52(3):593-6. doi: 10.1021/jm801101z. J Med Chem. 2009. PMID: 19138149 Free PMC article.

7

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.

Nikolovska-Coleska Z, Meagher JL, Jiang S, Kawamoto SA, Gao W, Yi H, Qin D, Roller PP, Stuckey JA, Wang S. Nikolovska-Coleska Z, et al. Among authors: qin d. Anal Biochem. 2008 Mar 1;374(1):87-98. doi: 10.1016/j.ab.2007.10.032. Epub 2007 Nov 20. Anal Biochem. 2008. PMID: 18023397

8

Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.

Bai J, Liao C, Liu Y, Qin X, Chen J, Qiu Y, Qin D, Li Z, Tu ZC, Jiang S. Bai J, et al. Among authors: qin d, qin x. J Med Chem. 2016 Jun 23;59(12):5766-79. doi: 10.1021/acs.jmedchem.6b00324. Epub 2016 Jun 13. J Med Chem. 2016. PMID: 27224875

9

Synthesis of [1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-ones through copper-catalyzed tandem reactions of N-(2-haloaryl)propiolamides with sodium azide.

Yan J, Zhou F, Qin D, Cai T, Ding K, Cai Q. Yan J, et al. Among authors: qin d. Org Lett. 2012 Mar 2;14(5):1262-5. doi: 10.1021/ol300114w. Epub 2012 Feb 15. Org Lett. 2012. PMID: 22335274

10

Inhibition of viral adhesion and infection by sialic-acid-conjugated dendritic polymers.

Reuter JD, Myc A, Hayes MM, Gan Z, Roy R, Qin D, Yin R, Piehler LT, Esfand R, Tomalia DA, Baker JR Jr. Reuter JD, et al. Among authors: qin d. Bioconjug Chem. 1999 Mar-Apr;10(2):271-8. doi: 10.1021/bc980099n. Bioconjug Chem. 1999. PMID: 10077477

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