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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. Wellington CL, et al. Among authors: ellerby lm. J Biol Chem. 1998 Apr 10;273(15):9158-67. doi: 10.1074/jbc.273.15.9158. J Biol Chem. 1998. PMID: 9535906 Free article.
Calpain activation in Huntington's disease.
Gafni J, Ellerby LM. Gafni J, et al. Among authors: ellerby lm. J Neurosci. 2002 Jun 15;22(12):4842-9. doi: 10.1523/JNEUROSCI.22-12-04842.2002. J Neurosci. 2002. PMID: 12077181 Free PMC article.
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Wellington CL, et al. Among authors: ellerby lm. J Neurosci. 2002 Sep 15;22(18):7862-72. doi: 10.1523/JNEUROSCI.22-18-07862.2002. J Neurosci. 2002. PMID: 12223539 Free PMC article.
An artificially designed pore-forming protein with anti-tumor effects.
Ellerby HM, Lee S, Ellerby LM, Chen S, Kiyota T, del Rio G, Sugihara G, Sun Y, Bredesen DE, Arap W, Pasqualini R. Ellerby HM, et al. Among authors: ellerby lm. J Biol Chem. 2003 Sep 12;278(37):35311-6. doi: 10.1074/jbc.M300474200. Epub 2003 May 14. J Biol Chem. 2003. PMID: 12750379 Free article.
111 results