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Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs.
Villeneuve L, Girard H, Fortier LC, Gagné JF, Guillemette C. Villeneuve L, et al. Among authors: guillemette c. J Pharmacol Exp Ther. 2003 Oct;307(1):117-28. doi: 10.1124/jpet.103.054072. Epub 2003 Aug 27. J Pharmacol Exp Ther. 2003. PMID: 12944498
Glucuronidation and the UDP-glucuronosyltransferases in health and disease.
Wells PG, Mackenzie PI, Chowdhury JR, Guillemette C, Gregory PA, Ishii Y, Hansen AJ, Kessler FK, Kim PM, Chowdhury NR, Ritter JK. Wells PG, et al. Among authors: guillemette c. Drug Metab Dispos. 2004 Mar;32(3):281-90. doi: 10.1124/dmd.32.3.281. Drug Metab Dispos. 2004. PMID: 14977861 Review.
Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.
Girard H, Court MH, Bernard O, Fortier LC, Villeneuve L, Hao Q, Greenblatt DJ, von Moltke LL, Perussed L, Guillemette C. Girard H, et al. Among authors: guillemette c. Pharmacogenetics. 2004 Aug;14(8):501-15. doi: 10.1097/01.fpc.0000114754.08559.27. Pharmacogenetics. 2004. PMID: 15284532
Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.
Lépine J, Bernard O, Plante M, Têtu B, Pelletier G, Labrie F, Bélanger A, Guillemette C. Lépine J, et al. Among authors: guillemette c. J Clin Endocrinol Metab. 2004 Oct;89(10):5222-32. doi: 10.1210/jc.2004-0331. J Clin Endocrinol Metab. 2004. PMID: 15472229
203 results