Curran DP - Search Results

1

Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin.

Tangirala RS, Antony S, Agama K, Pommier Y, Anderson BD, Bevins R, Curran DP. Tangirala RS, et al. Among authors: curran dp. Bioorg Med Chem. 2006 Sep 15;14(18):6202-12. doi: 10.1016/j.bmc.2006.05.073. Epub 2006 Jun 21. Bioorg Med Chem. 2006. PMID: 16793274

2

"Propylene spaced" allyl tin reagents: a new class of fluorous tin reagents for allylations under radical and metal-catalyzed conditions.

Curran DP, Luo Z, Degenkolb P. Curran DP, et al. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2403-8. doi: 10.1016/s0960-894x(98)00435-1. Bioorg Med Chem Lett. 1998. PMID: 9873550

3

Novel A,B,E-ring-modified camptothecins displaying high lipophilicity and markedly improved human blood stabilities.

Bom D, Curran DP, Chavan AJ, Kruszewski S, Zimmer SG, Fraley KA, Burke TG. Bom D, et al. Among authors: curran dp. J Med Chem. 1999 Aug 12;42(16):3018-22. doi: 10.1021/jm9902279. J Med Chem. 1999. PMID: 10447944 No abstract available.

4

The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity.

Bom D, Curran DP, Kruszewski S, Zimmer SG, Thompson Strode J, Kohlhagen G, Du W, Chavan AJ, Fraley KA, Bingcang AL, Latus LJ, Pommier Y, Burke TG. Bom D, et al. Among authors: curran dp. J Med Chem. 2000 Oct 19;43(21):3970-80. doi: 10.1021/jm000144o. J Med Chem. 2000. PMID: 11052802

5

The cascade radical annulation approach to new analogues of camptothecins. Combinatorial synthesis of silatecans and homosilatecans.

Curran DP, Josien H, Bom D, Gabarda AE, Du W. Curran DP, et al. Ann N Y Acad Sci. 2000;922:112-21. doi: 10.1111/j.1749-6632.2000.tb07030.x. Ann N Y Acad Sci. 2000. PMID: 11193887 Review.

6

The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity.

Bom D, Curran DP, Zhang J, Zimmer SG, Bevins R, Kruszewski S, Howe JN, Bingcang A, Latus LJ, Burke TG. Bom D, et al. Among authors: curran dp. J Control Release. 2001 Jul 6;74(1-3):325-33. doi: 10.1016/s0168-3659(01)00343-1. J Control Release. 2001. PMID: 11489514

7

Synthesis and evaluation of a novel E-ring modified alpha-hydroxy keto ether analogue of camptothecin.

Du W, Curran DP, Bevins RL, Zimmer SG, Zhang J, Burke TG. Du W, et al. Among authors: curran dp. Bioorg Med Chem. 2002 Jan;10(1):103-10. doi: 10.1016/s0968-0896(01)00252-8. Bioorg Med Chem. 2002. PMID: 11738612

8

Semisynthesis of DB-67 and other silatecans from camptothecin by thiol-promoted addition of silyl radicals.

Du W, Kaskar B, Blumbergs P, Subramanian PK, Curran DP. Du W, et al. Among authors: curran dp. Bioorg Med Chem. 2003 Feb 6;11(3):451-8. doi: 10.1016/s0968-0896(02)00437-6. Bioorg Med Chem. 2003. PMID: 12517440

9

Simplified discodermolide analogues: synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents.

Choy N, Shin Y, Nguyen PQ, Curran DP, Balachandran R, Madiraju C, Day BW. Choy N, et al. Among authors: curran dp. J Med Chem. 2003 Jul 3;46(14):2846-64. doi: 10.1021/jm0204136. J Med Chem. 2003. PMID: 12825928

10

Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide.

Mínguez JM, Kim SY, Giuliano KA, Balachandran R, Madiraju C, Day BW, Curran DP. Mínguez JM, et al. Among authors: curran dp. Bioorg Med Chem. 2003 Jul 31;11(15):3335-57. doi: 10.1016/s0968-0896(03)00186-x. Bioorg Med Chem. 2003. PMID: 12837544

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