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Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
Wishka DG, Walker DP, Yates KM, Reitz SC, Jia S, Myers JK, Olson KL, Jacobsen EJ, Wolfe ML, Groppi VE, Hanchar AJ, Thornburgh BA, Cortes-Burgos LA, Wong EH, Staton BA, Raub TJ, Higdon NR, Wall TM, Hurst RS, Walters RR, Hoffmann WE, Hajos M, Franklin S, Carey G, Gold LH, Cook KK, Sands SB, Zhao SX, Soglia JR, Kalgutkar AS, Arneric SP, Rogers BN. Wishka DG, et al. Among authors: gold lh. J Med Chem. 2006 Jul 13;49(14):4425-36. doi: 10.1021/jm0602413. J Med Chem. 2006. PMID: 16821801
Synthesis and SAR of tolylamine 5-HT6 antagonists.
Singer JM, Wilson MW, Johnson PD, Graham SR, Cooke LW, Roof RL, Boxer PA, Gold LH, Meltzer LT, Janssen A, Roush N, Campbell JE, Su TZ, Hurst SI, Stoner CL, Schwarz JB. Singer JM, et al. Among authors: gold lh. Bioorg Med Chem Lett. 2009 May 1;19(9):2409-12. doi: 10.1016/j.bmcl.2009.03.077. Epub 2009 Mar 25. Bioorg Med Chem Lett. 2009. PMID: 19346128
Asenapine effects in animal models of psychosis and cognitive function.
Marston HM, Young JW, Martin FD, Serpa KA, Moore CL, Wong EH, Gold L, Meltzer LT, Azar MR, Geyer MA, Shahid M. Marston HM, et al. Psychopharmacology (Berl). 2009 Nov;206(4):699-714. doi: 10.1007/s00213-009-1570-z. Epub 2009 May 22. Psychopharmacology (Berl). 2009. PMID: 19462162 Free PMC article.
161 results