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The isoflavone Equol mediates rapid vascular relaxation: Ca2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells.
Joy S, Siow RC, Rowlands DJ, Becker M, Wyatt AW, Aaronson PI, Coen CW, Kallo I, Jacob R, Mann GE. Joy S, et al. Among authors: jacob r. J Biol Chem. 2006 Sep 15;281(37):27335-45. doi: 10.1074/jbc.M602803200. Epub 2006 Jul 13. J Biol Chem. 2006. PMID: 16840783 Free article.
A PP2A-mediated feedback mechanism controls Ca2+-dependent NO synthesis under physiological oxygen.
Keeley TP, Siow RCM, Jacob R, Mann GE. Keeley TP, et al. Among authors: jacob r. FASEB J. 2017 Dec;31(12):5172-5183. doi: 10.1096/fj.201700211R. Epub 2017 Jul 31. FASEB J. 2017. PMID: 28760745 Free PMC article.
Furthermore, an explicit delineation between physiologic normoxia and genuine hypoxia is defined here, with implications for our understanding of pathophysiological hypoxia.-Keeley, T. P., Siow, R. C. M., Jacob, R., Mann, G. E. A PP2A-mediated feedback mechan …
Furthermore, an explicit delineation between physiologic normoxia and genuine hypoxia is defined here, with implications for our understandi …
Reduced SERCA activity underlies dysregulation of Ca2+ homeostasis under atmospheric O2 levels.
Keeley TP, Siow RCM, Jacob R, Mann GE. Keeley TP, et al. Among authors: jacob r. FASEB J. 2018 May;32(5):2531-2538. doi: 10.1096/fj.201700685RRR. Epub 2017 Dec 22. FASEB J. 2018. PMID: 29273673 Free PMC article.
Taken together, these results demonstrate that culturing cells under hyperoxic conditions reduces their ability to efficiently regulate [Ca(2+)](i), resulting in greater sensitivity to cytotoxic stimuli.-Keeley, T. P., Siow, R. C. M., Jacob, R., Mann, G. E. R …
Taken together, these results demonstrate that culturing cells under hyperoxic conditions reduces their ability to efficiently regulate [Ca( …
Calcium oscillations in endothelial cells.
Jacob R. Jacob R. Cell Calcium. 1991 Feb-Mar;12(2-3):127-34. doi: 10.1016/0143-4160(91)90014-6. Cell Calcium. 1991. PMID: 2059989 Review.
1,534 results