Zhou H - Search Results

1

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis.

Baker SJ, Zhang YK, Akama T, Lau A, Zhou H, Hernandez V, Mao W, Alley MR, Sanders V, Plattner JJ. Baker SJ, et al. Among authors: zhou h. J Med Chem. 2006 Jul 27;49(15):4447-50. doi: 10.1021/jm0603724. J Med Chem. 2006. PMID: 16854048

2

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.

Rock FL, Mao W, Yaremchuk A, Tukalo M, Crépin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, Alley MR. Rock FL, et al. Among authors: zhou h. Science. 2007 Jun 22;316(5832):1759-61. doi: 10.1126/science.1142189. Science. 2007. PMID: 17588934

3

Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.

Akama T, Baker SJ, Zhang YK, Hernandez V, Zhou H, Sanders V, Freund Y, Kimura R, Maples KR, Plattner JJ. Akama T, et al. Among authors: zhou h. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32. doi: 10.1016/j.bmcl.2009.03.007. Epub 2009 Mar 9. Bioorg Med Chem Lett. 2009. PMID: 19303290

4

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.

Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Ye L, Zhou H, Waterson D, Gamo FJ, Sanz LM, Ge M, Li Z, Li L, Wang H, Cui H. Zhang YK, et al. Among authors: zhou h, zhou y. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1299-307. doi: 10.1016/j.bmcl.2011.12.096. Epub 2011 Dec 28. Bioorg Med Chem Lett. 2012. PMID: 22243961

5

Discovery of novel benzoxaborole-based potent antitrypanosomal agents.

Ding D, Zhao Y, Meng Q, Xie D, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang YK, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang KH, Ratnam J, McKerrow JH, Jacobs RT, Zhou H, Plattner JJ. Ding D, et al. Among authors: zhou h. ACS Med Chem Lett. 2010 Apr 6;1(4):165-9. doi: 10.1021/ml100013s. eCollection 2010 Jul 8. ACS Med Chem Lett. 2010. PMID: 24900190 Free PMC article.

6

Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents.

Ding D, Meng Q, Gao G, Zhao Y, Wang Q, Nare B, Jacobs R, Rock F, Alley MR, Plattner JJ, Chen G, Li D, Zhou H. Ding D, et al. Among authors: zhou h. J Med Chem. 2011 Mar 10;54(5):1276-87. doi: 10.1021/jm101225g. Epub 2011 Feb 15. J Med Chem. 2011. PMID: 21322634

7

Chalcone-benzoxaborole hybrid molecules as potent antitrypanosomal agents.

Qiao Z, Wang Q, Zhang F, Wang Z, Bowling T, Nare B, Jacobs RT, Zhang J, Ding D, Liu Y, Zhou H. Qiao Z, et al. Among authors: zhou h. J Med Chem. 2012 Apr 12;55(7):3553-7. doi: 10.1021/jm2012408. Epub 2012 Mar 14. J Med Chem. 2012. PMID: 22360533

8

Chalcone-benzoxaborole hybrids as novel anticancer agents.

Zhang J, Yang F, Qiao Z, Zhu M, Zhou H. Zhang J, et al. Among authors: zhou h. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5797-5801. doi: 10.1016/j.bmcl.2016.10.024. Epub 2016 Oct 12. Bioorg Med Chem Lett. 2016. PMID: 28327308

9

Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei.

Wu P, Zhang J, Meng Q, Nare B, Jacobs RT, Zhou H. Wu P, et al. Among authors: zhou h. Eur J Med Chem. 2014 Jun 23;81:59-75. doi: 10.1016/j.ejmech.2014.04.079. Epub 2014 Apr 29. Eur J Med Chem. 2014. PMID: 24826816

10

Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase.

Hu QH, Liu RJ, Fang ZP, Zhang J, Ding YY, Tan M, Wang M, Pan W, Zhou HC, Wang ED. Hu QH, et al. Sci Rep. 2013;3:2475. doi: 10.1038/srep02475. Sci Rep. 2013. PMID: 23959225 Free PMC article.

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