Pak RH - Search Results

1

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J, Sydor JR, Tibbitts TT, Tong JK, Adams J, Palombella VJ. Ge J, et al. Among authors: pak rh. J Med Chem. 2006 Jul 27;49(15):4606-15. doi: 10.1021/jm0603116. J Med Chem. 2006. PMID: 16854066

2

Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.

Sydor JR, Normant E, Pien CS, Porter JR, Ge J, Grenier L, Pak RH, Ali JA, Dembski MS, Hudak J, Patterson J, Penders C, Pink M, Read MA, Sang J, Woodward C, Zhang Y, Grayzel DS, Wright J, Barrett JA, Palombella VJ, Adams J, Tong JK. Sydor JR, et al. Among authors: pak rh. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17408-13. doi: 10.1073/pnas.0608372103. Epub 2006 Nov 7. Proc Natl Acad Sci U S A. 2006. PMID: 17090671 Free PMC article.

3

Amino-caprolactam derivatives as gamma-secretase inhibitors.

Parker MF, Bronson JJ, Barten DM, Corsa JA, Du W, Felsenstein KM, Guss VL, Izzarelli D, Loo A, McElhone KE, Marcin LR, Padmanabha R, Pak R, Polson CT, Toyn JH, Varma S, Wang J, Wong V, Zheng M, Roberts SB. Parker MF, et al. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5790-5. doi: 10.1016/j.bmcl.2007.08.047. Epub 2007 Aug 26. Bioorg Med Chem Lett. 2007. PMID: 17869509

4

Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells.

Peng C, Brain J, Hu Y, Goodrich A, Kong L, Grayzel D, Pak R, Read M, Li S. Peng C, et al. Blood. 2007 Jul 15;110(2):678-85. doi: 10.1182/blood-2006-10-054098. Epub 2007 Mar 29. Blood. 2007. PMID: 17395781 Free PMC article.

5

Editorial: Chemistry of Linkers for Conjugated Biotherapeutics.

Pak RH. Pak RH. Curr Top Med Chem. 2017;17(32):3391-3392. doi: 10.2174/156802661732180223104750. Curr Top Med Chem. 2017. PMID: 29500889 No abstract available.

6

Antibody-Drug Conjugates: Design, Formulation and Physicochemical Stability.

Singh SK, Luisi DL, Pak RH. Singh SK, et al. Among authors: pak rh. Pharm Res. 2015 Nov;32(11):3541-71. doi: 10.1007/s11095-015-1704-4. Epub 2015 May 19. Pharm Res. 2015. PMID: 25986175 Review.

7

Total solid-phase synthesis of 1,4,7,10-tetraazacyclododecane-N,N', N'',N'''-tetraacetic acid-functionalized peptides for radioimmunotherapy.

Peterson JJ, Pak RH, Meares CF. Peterson JJ, et al. Among authors: pak rh. Bioconjug Chem. 1999 Mar-Apr;10(2):316-20. doi: 10.1021/bc980118t. Bioconjug Chem. 1999. PMID: 10077483

8

New anti-Cu-TETA and anti-Y-DOTA monoclonal antibodies for potential use in the pre-targeted delivery of radiopharmaceuticals to tumor.

Feng X, Pak RH, Kroger LA, Moran JK, DeNardo DG, Meares CF, DeNardo GL, DeNardo SJ. Feng X, et al. Among authors: pak rh. Hybridoma. 1998 Apr;17(2):125-32. doi: 10.1089/hyb.1998.17.125. Hybridoma. 1998. PMID: 9627052

9

Bispecific antibody mediated targeting of nido-carboranes to human colon carcinoma cells.

Primus FJ, Pak RH, Richard-Dickson KJ, Szalai G, Bolen JL Jr, Kane RR, Hawthorne MF. Primus FJ, et al. Among authors: pak rh. Bioconjug Chem. 1996 Sep-Oct;7(5):532-5. doi: 10.1021/bc960050m. Bioconjug Chem. 1996. PMID: 8889012

10

Preparation and properties of nido-carborane-specific monoclonal antibodies for potential use in boron neutron capture therapy for cancer.

Pak RH, Primus FJ, Rickard-Dickson KJ, Ng LL, Kane RR, Hawthorne MF. Pak RH, et al. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6986-90. doi: 10.1073/pnas.92.15.6986. Proc Natl Acad Sci U S A. 1995. PMID: 7624355 Free PMC article.

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