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The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation.
Seng TJ, Low JS, Li H, Cui Y, Goh HK, Wong ML, Srivastava G, Sidransky D, Califano J, Steenbergen RD, Rha SY, Tan J, Hsieh WS, Ambinder RF, Lin X, Chan AT, Tao Q. Seng TJ, et al. Among authors: li h. Oncogene. 2007 Feb 8;26(6):934-44. doi: 10.1038/sj.onc.1209839. Epub 2006 Jul 24. Oncogene. 2007. PMID: 16862168
Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas.
Jin H, Wang X, Ying J, Wong AH, Li H, Lee KY, Srivastava G, Chan AT, Yeo W, Ma BB, Putti TC, Lung ML, Shen ZY, Xu LY, Langford C, Tao Q. Jin H, et al. Among authors: li h. Oncogene. 2007 Nov 22;26(53):7490-8. doi: 10.1038/sj.onc.1210559. Epub 2007 Jun 4. Oncogene. 2007. PMID: 17546048 Free PMC article.
EMX2 is epigenetically silenced and suppresses growth in human lung cancer.
Okamoto J, Hirata T, Chen Z, Zhou HM, Mikami I, Li H, Yagui-Beltran A, Johansson M, Coussens LM, Clement G, Shi Y, Zhang F, Koizumi K, Shimizu K, Jablons D, He B. Okamoto J, et al. Among authors: li h. Oncogene. 2010 Nov 4;29(44):5969-75. doi: 10.1038/onc.2010.330. Epub 2010 Aug 9. Oncogene. 2010. PMID: 20697358 Free PMC article.
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