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Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists.
Blanc-Delmas E, Lebegue N, Wallez V, Leclerc V, Yous S, Carato P, Farce A, Bennejean C, Renard P, Caignard DH, Audinot-Bouchez V, Chomarat P, Boutin J, Hennuyer N, Louche K, Carmona MC, Staels B, Pénicaud L, Casteilla L, Lonchampt M, Dacquet C, Chavatte P, Berthelot P, Lesieur D. Blanc-Delmas E, et al. Among authors: caignard dh. Bioorg Med Chem. 2006 Nov 15;14(22):7377-91. doi: 10.1016/j.bmc.2006.07.029. Epub 2006 Aug 2. Bioorg Med Chem. 2006. PMID: 16887353
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.
Parmenon C, Guillard J, Caignard DH, Hennuyer N, Staels B, Audinot-Bouchez V, Boutin JA, Dacquet C, Ktorza A, Viaud-Massuard MC. Parmenon C, et al. Among authors: caignard dh. Bioorg Med Chem Lett. 2009 May 15;19(10):2683-7. doi: 10.1016/j.bmcl.2009.03.143. Epub 2009 Apr 1. Bioorg Med Chem Lett. 2009. PMID: 19376700
Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.
Pirat C, Dacquet C, Leclerc V, Hennuyer N, Beucher-Gaudin M, Zanirato G, Géant A, Staels B, Ktorza A, Farce A, Caignard DH, Berthelot P, Lebegue N. Pirat C, et al. Among authors: caignard dh. Eur J Med Chem. 2017 Sep 8;137:310-326. doi: 10.1016/j.ejmech.2017.06.006. Epub 2017 Jun 12. Eur J Med Chem. 2017. PMID: 28609708
Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists.
Hurtevent A, Le Naour M, Leclerc V, Carato P, Melnyk P, Hennuyer N, Staels B, Beucher-Gaudin M, Caignard DH, Dacquet C, Lebegue N. Hurtevent A, et al. Among authors: caignard dh. J Enzyme Inhib Med Chem. 2020 Dec;35(1):524-538. doi: 10.1080/14756366.2020.1713771. J Enzyme Inhib Med Chem. 2020. PMID: 31939313 Free PMC article.
Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands.
Poissonnier-Durieux S, Ettaoussi M, Pérès B, Boutin JA, Audinot V, Bennejean C, Delagrange P, Caignard DH, Renard P, Berthelot P, Lesieur D, Yous S. Poissonnier-Durieux S, et al. Among authors: caignard dh. Bioorg Med Chem. 2008 Sep 15;16(18):8339-48. doi: 10.1016/j.bmc.2008.08.052. Epub 2008 Aug 27. Bioorg Med Chem. 2008. PMID: 18778943
Studies towards the conception of new selective PPARbeta/delta ligands.
Basséne CE, Suzenet F, Hennuyer N, Staels B, Caignard DH, Dacquet C, Renard P, Guillaumet G. Basséne CE, et al. Among authors: caignard dh. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4528-32. doi: 10.1016/j.bmcl.2006.06.028. Epub 2006 Jun 23. Bioorg Med Chem Lett. 2006. PMID: 16797985
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