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Amyotrophic lateral sclerosis and gene therapy.
Miller TM, Smith RA, Cleveland DW. Miller TM, et al. Among authors: cleveland dw. Nat Clin Pract Neurol. 2006 Sep;2(9):462-3. doi: 10.1038/ncpneuro0270. Nat Clin Pract Neurol. 2006. PMID: 16932606 Review. No abstract available.
Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant.
Bruijn LI, Beal MF, Becher MW, Schulz JB, Wong PC, Price DL, Cleveland DW. Bruijn LI, et al. Among authors: cleveland dw. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7606-11. doi: 10.1073/pnas.94.14.7606. Proc Natl Acad Sci U S A. 1997. PMID: 9207139 Free PMC article.
Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant.
Williamson TL, Bruijn LI, Zhu Q, Anderson KL, Anderson SD, Julien JP, Cleveland DW. Williamson TL, et al. Among authors: cleveland dw. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9631-6. doi: 10.1073/pnas.95.16.9631. Proc Natl Acad Sci U S A. 1998. PMID: 9689132 Free PMC article.
Has gene therapy for ALS arrived?
Miller TM, Cleveland DW. Miller TM, et al. Among authors: cleveland dw. Nat Med. 2003 Oct;9(10):1256-7. doi: 10.1038/nm1003-1256. Nat Med. 2003. PMID: 14520369 No abstract available.
Gene therapy for ALS delivers.
Boillée S, Cleveland DW. Boillée S, et al. Among authors: cleveland dw. Trends Neurosci. 2004 May;27(5):235-8. doi: 10.1016/j.tins.2004.03.002. Trends Neurosci. 2004. PMID: 15111001 Review.
425 results