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Page 1
Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.
Hopkins CR, O'neil SV, Laufersweiler MC, Wang Y, Pokross M, Mekel M, Evdokimov A, Walter R, Kontoyianni M, Petrey ME, Sabatakos G, Roesgen JT, Richardson E, Demuth TP Jr. Hopkins CR, et al. Among authors: pokross m. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5659-63. doi: 10.1016/j.bmcl.2006.08.003. Epub 2006 Aug 21. Bioorg Med Chem Lett. 2006. PMID: 16919947
Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors.
Warshakoon NC, Wu S, Boyer A, Kawamoto R, Sheville J, Renock S, Xu K, Pokross M, Zhou S, Winter C, Walter R, Mekel M, Evdokimov AG. Warshakoon NC, et al. Among authors: pokross m. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5517-22. doi: 10.1016/j.bmcl.2006.08.040. Epub 2006 Aug 22. Bioorg Med Chem Lett. 2006. PMID: 16931007
1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors.
Klopfenstein SR, Evdokimov AG, Colson AO, Fairweather NT, Neuman JJ, Maier MB, Gray JL, Gerwe GS, Stake GE, Howard BW, Farmer JA, Pokross ME, Downs TR, Kasibhatla B, Peters KG. Klopfenstein SR, et al. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1574-8. doi: 10.1016/j.bmcl.2005.12.051. Epub 2006 Jan 4. Bioorg Med Chem Lett. 2006. PMID: 16386905
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
Amarasinghe KK, Evdokimov AG, Xu K, Clark CM, Maier MB, Srivastava A, Colson AO, Gerwe GS, Stake GE, Howard BW, Pokross ME, Gray JL, Peters KG. Amarasinghe KK, et al. Among authors: pokross me. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4252-6. doi: 10.1016/j.bmcl.2006.05.074. Epub 2006 Jun 12. Bioorg Med Chem Lett. 2006. PMID: 16759857
Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Evdokimov AG, Pokross M, Walter RL, Mekel M, Barnett BL, Amburgey J, Seibel WL, Soper SJ, Djung JF, Fairweather N, Diven C, Rastogi V, Grinius L, Klanke C, Siehnel R, Twinem T, Andrews R, Curnow A. Evdokimov AG, et al. Among authors: pokross m. Proteins. 2007 Feb 15;66(3):538-46. doi: 10.1002/prot.21207. Proteins. 2007. PMID: 17120228
Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Evdokimov AG, Pokross M, Walter R, Mekel M, Cox B, Li C, Bechard R, Genbauffe F, Andrews R, Diven C, Howard B, Rastogi V, Gray J, Maier M, Peters KG. Evdokimov AG, et al. Among authors: pokross m. Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1435-45. doi: 10.1107/S0907444906037784. Epub 2006 Nov 23. Acta Crystallogr D Biol Crystallogr. 2006. PMID: 17139078
Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines.
Natchus MG, Bookland RG, De B, Almstead NG, Pikul S, Janusz MJ, Heitmeyer SA, Hookfin EB, Hsieh LC, Dowty ME, Dietsch CR, Patel VS, Garver SM, Gu F, Pokross ME, Mieling GE, Baker TR, Foltz DJ, Peng SX, Bornes DM, Strojnowski MJ, Taiwo YO. Natchus MG, et al. Among authors: pokross me. J Med Chem. 2000 Dec 28;43(26):4948-63. doi: 10.1021/jm000246e. J Med Chem. 2000. PMID: 11150165
29 results