Petrocchi A - Search Results

1

A series of novel, potent, and selective histone deacetylase inhibitors.

Jones P, Altamura S, Chakravarty PK, Cecchetti O, De Francesco R, Gallinari P, Ingenito R, Meinke PT, Petrocchi A, Rowley M, Scarpelli R, Serafini S, Steinkühler C. Jones P, et al. Among authors: petrocchi a. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5948-52. doi: 10.1016/j.bmcl.2006.09.002. Epub 2006 Sep 20. Bioorg Med Chem Lett. 2006. PMID: 16987657

2

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase.

Summa V, Petrocchi A, Pace P, Matassa VG, De Francesco R, Altamura S, Tomei L, Koch U, Neuner P. Summa V, et al. Among authors: petrocchi a. J Med Chem. 2004 Jan 1;47(1):14-7. doi: 10.1021/jm0342109. J Med Chem. 2004. PMID: 14695815

3

HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.

Summa V, Petrocchi A, Matassa VG, Taliani M, Laufer R, De Francesco R, Altamura S, Pace P. Summa V, et al. Among authors: petrocchi a. J Med Chem. 2004 Oct 21;47(22):5336-9. doi: 10.1021/jm0494669. J Med Chem. 2004. PMID: 15481971

4

From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety.

Petrocchi A, Koch U, Matassa VG, Pacini B, Stillmock KA, Summa V. Petrocchi A, et al. Bioorg Med Chem Lett. 2007 Jan 15;17(2):350-3. doi: 10.1016/j.bmcl.2006.10.054. Epub 2006 Oct 25. Bioorg Med Chem Lett. 2007. PMID: 17107799

5

4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.

Summa V, Petrocchi A, Matassa VG, Gardelli C, Muraglia E, Rowley M, Paz OG, Laufer R, Monteagudo E, Pace P. Summa V, et al. Among authors: petrocchi a. J Med Chem. 2006 Nov 16;49(23):6646-9. doi: 10.1021/jm060854f. J Med Chem. 2006. PMID: 17154493

6

Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.

Pace P, Di Francesco ME, Gardelli C, Harper S, Muraglia E, Nizi E, Orvieto F, Petrocchi A, Poma M, Rowley M, Scarpelli R, Laufer R, Gonzalez Paz O, Monteagudo E, Bonelli F, Hazuda D, Stillmock KA, Summa V. Pace P, et al. Among authors: petrocchi a. J Med Chem. 2007 May 3;50(9):2225-39. doi: 10.1021/jm070027u. Epub 2007 Apr 12. J Med Chem. 2007. PMID: 17428043

7

Studies of metabolism and disposition of potent human immunodeficiency virus (HIV) integrase inhibitors using 19F-NMR spectroscopy.

Monteagudo E, Pesci S, Taliani M, Fiore F, Petrocchi A, Nizi E, Rowley M, Laufer R, Summa V. Monteagudo E, et al. Among authors: petrocchi a. Xenobiotica. 2007 Sep;37(9):1000-12. doi: 10.1080/00498250701652323. Xenobiotica. 2007. PMID: 17896326

8

Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.

Summa V, Petrocchi A, Bonelli F, Crescenzi B, Donghi M, Ferrara M, Fiore F, Gardelli C, Gonzalez Paz O, Hazuda DJ, Jones P, Kinzel O, Laufer R, Monteagudo E, Muraglia E, Nizi E, Orvieto F, Pace P, Pescatore G, Scarpelli R, Stillmock K, Witmer MV, Rowley M. Summa V, et al. Among authors: petrocchi a. J Med Chem. 2008 Sep 25;51(18):5843-55. doi: 10.1021/jm800245z. J Med Chem. 2008. PMID: 18763751

9

N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors.

Petrocchi A, Jones P, Rowley M, Fiore F, Summa V. Petrocchi A, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4245-9. doi: 10.1016/j.bmcl.2009.05.098. Epub 2009 May 29. Bioorg Med Chem Lett. 2009. PMID: 19523819

10

Inhibitors of the hepatitis C virus NS3 protease with basic amine functionality at the P3-amino acid N-terminus: discovery and optimization of a new series of P2-P4 macrocycles.

Harper S, Ferrara M, Crescenzi B, Pompei M, Palumbi MC, DiMuzio JM, Donghi M, Fiore F, Koch U, Liverton NJ, Pesci S, Petrocchi A, Rowley M, Summa V, Gardelli C. Harper S, et al. Among authors: petrocchi a. J Med Chem. 2009 Aug 13;52(15):4820-37. doi: 10.1021/jm900372w. J Med Chem. 2009. PMID: 19624135

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