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Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
Whittaker GC, Burshtyn DN, Orr SJ, Quigley L, Hodge DL, Pascal V, Zhang W, McVicar DW. Whittaker GC, et al. Among authors: orr sj. Blood. 2008 Oct 1;112(7):2869-77. doi: 10.1182/blood-2007-11-121590. Epub 2008 Jul 21. Blood. 2008. PMID: 18645037 Free PMC article.
The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.
Whittaker GC, Orr SJ, Quigley L, Hughes L, Francischetti IM, Zhang W, McVicar DW. Whittaker GC, et al. Among authors: orr sj. J Biol Chem. 2010 Jan 29;285(5):2976-85. doi: 10.1074/jbc.M109.038398. Epub 2009 Nov 30. J Biol Chem. 2010. PMID: 19948717 Free PMC article.
LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.
Orr SJ, Burg AR, Chan T, Quigley L, Jones GW, Ford JW, Hodge D, Razzook C, Sarhan J, Jones YL, Whittaker GC, Boelte KC, Lyakh L, Cardone M, O'Connor GM, Tan C, Li H, Anderson SK, Jones SA, Zhang W, Taylor PR, Trinchieri G, McVicar DW. Orr SJ, et al. PLoS Pathog. 2013 May;9(5):e1003357. doi: 10.1371/journal.ppat.1003357. Epub 2013 May 9. PLoS Pathog. 2013. PMID: 23675302 Free PMC article.
39 results