Khatib AM - Search Results

1

Proprotein convertases: lessons from knockouts.

Scamuffa N, Calvo F, Chrétien M, Seidah NG, Khatib AM. Scamuffa N, et al. Among authors: khatib am. FASEB J. 2006 Oct;20(12):1954-63. doi: 10.1096/fj.05-5491rev. FASEB J. 2006. PMID: 17012247 Review.

2

Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions.

Khatib AM, Siegfried G, Prat A, Luis J, Chrétien M, Metrakos P, Seidah NG. Khatib AM, et al. J Biol Chem. 2001 Aug 17;276(33):30686-93. doi: 10.1074/jbc.M101725200. Epub 2001 Jun 11. J Biol Chem. 2001. PMID: 11402025 Free article.

3

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy.

Khatib AM, Siegfried G, Chrétien M, Metrakos P, Seidah NG. Khatib AM, et al. Am J Pathol. 2002 Jun;160(6):1921-35. doi: 10.1016/S0002-9440(10)61140-6. Am J Pathol. 2002. PMID: 12057895 Free PMC article. Review.

4

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

Siegfried G, Khatib AM, Benjannet S, Chrétien M, Seidah NG. Siegfried G, et al. Among authors: khatib am. Cancer Res. 2003 Apr 1;63(7):1458-63. Cancer Res. 2003. PMID: 12670890

5

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.

Siegfried G, Basak A, Cromlish JA, Benjannet S, Marcinkiewicz J, Chrétien M, Seidah NG, Khatib AM. Siegfried G, et al. Among authors: khatib am. J Clin Invest. 2003 Jun;111(11):1723-32. doi: 10.1172/JCI17220. J Clin Invest. 2003. PMID: 12782675 Free PMC article.

6

Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases.

Siegfried G, Basak A, Prichett-Pejic W, Scamuffa N, Ma L, Benjannet S, Veinot JP, Calvo F, Seidah N, Khatib AM. Siegfried G, et al. Among authors: khatib am. Oncogene. 2005 Oct 20;24(46):6925-35. doi: 10.1038/sj.onc.1208838. Oncogene. 2005. PMID: 16007151

7

Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases.

Tzimas GN, Chevet E, Jenna S, Nguyên DT, Khatib AM, Marcus V, Zhang Y, Chrétien M, Seidah N, Metrakos P. Tzimas GN, et al. Among authors: khatib am. BMC Cancer. 2005 Nov 17;5:149. doi: 10.1186/1471-2407-5-149. BMC Cancer. 2005. PMID: 16293189 Free PMC article.

8

The proprotein convertases and their implication in sterol and/or lipid metabolism.

Seidah NG, Khatib AM, Prat A. Seidah NG, et al. Among authors: khatib am. Biol Chem. 2006 Jul;387(7):871-7. doi: 10.1515/BC.2006.110. Biol Chem. 2006. PMID: 16913836 Review.

9

Potential opportunity in the development of new therapeutic agents based on endogenous and exogenous inhibitors of the proprotein convertases.

Bontemps Y, Scamuffa N, Calvo F, Khatib AM. Bontemps Y, et al. Among authors: khatib am. Med Res Rev. 2007 Sep;27(5):631-48. doi: 10.1002/med.20072. Med Res Rev. 2007. PMID: 17019676 Free PMC article. Review.

10

Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.

Lapierre M, Siegfried G, Scamuffa N, Bontemps Y, Calvo F, Seidah NG, Khatib AM. Lapierre M, et al. Among authors: khatib am. Cancer Res. 2007 Oct 1;67(19):9030-4. doi: 10.1158/0008-5472.CAN-07-0807. Cancer Res. 2007. PMID: 17909005

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