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St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis.
Hu ZP, Yang XX, Chan SY, Xu AL, Duan W, Zhu YZ, Sheu FS, Boelsterli UA, Chan E, Zhang Q, Wang JC, Ee PL, Koh HL, Huang M, Zhou SF. Hu ZP, et al. Among authors: zhu yz. Toxicol Appl Pharmacol. 2006 Oct 15;216(2):225-37. doi: 10.1016/j.taap.2006.05.020. Epub 2006 Jul 21. Toxicol Appl Pharmacol. 2006. PMID: 17015070
The very C-terminus of protein kinase Cepsilon is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1.
Zhu Y, Smith D, Verma C, Lim WG, Tan BJ, Armstrong JS, Zhou S, Chan E, Tan SL, Zhu YZ, Cheung NS, Duan W. Zhu Y, et al. Among authors: zhu yz. Cell Signal. 2006 Jun;18(6):807-18. doi: 10.1016/j.cellsig.2005.07.005. Epub 2005 Aug 30. Cell Signal. 2006. PMID: 16137858
Topotecan is a substrate for multidrug resistance associated protein 4.
Tian Q, Zhang J, Chan SY, Tan TM, Duan W, Huang M, Zhu YZ, Chan E, Yu Q, Nie YQ, Ho PC, Li Q, Ng KY, Yang HY, Wei H, Bian JS, Zhou SF. Tian Q, et al. Among authors: zhu yz. Curr Drug Metab. 2006 Jan;7(1):105-18. doi: 10.2174/138920006774832550. Curr Drug Metab. 2006. PMID: 16454695
538 results