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A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
Shishodia S, Sethi G, Konopleva M, Andreeff M, Aggarwal BB. Shishodia S, et al. Among authors: aggarwal bb. Clin Cancer Res. 2006 Mar 15;12(6):1828-38. doi: 10.1158/1078-0432.CCR-05-2044. Clin Cancer Res. 2006. PMID: 16551868
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
Sandur SK, Ichikawa H, Sethi G, Ahn KS, Aggarwal BB. Sandur SK, et al. Among authors: aggarwal bb. J Biol Chem. 2006 Jun 23;281(25):17023-17033. doi: 10.1074/jbc.M601595200. Epub 2006 Apr 19. J Biol Chem. 2006. PMID: 16624823 Free article.
Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.
Ahn KS, Sethi G, Jain AK, Jaiswal AK, Aggarwal BB. Ahn KS, et al. Among authors: aggarwal bb. J Biol Chem. 2006 Jul 21;281(29):19798-808. doi: 10.1074/jbc.M601162200. Epub 2006 May 8. J Biol Chem. 2006. PMID: 16682409 Free article.
Inflammation and cancer: how hot is the link?
Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G. Aggarwal BB, et al. Biochem Pharmacol. 2006 Nov 30;72(11):1605-21. doi: 10.1016/j.bcp.2006.06.029. Epub 2006 Aug 4. Biochem Pharmacol. 2006. PMID: 16889756 Review.
658 results