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Page 1
Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction.
Hardcastle IR, Ahmed SU, Atkins H, Calvert AH, Curtin NJ, Farnie G, Golding BT, Griffin RJ, Guyenne S, Hutton C, Källblad P, Kemp SJ, Kitching MS, Newell DR, Norbedo S, Northen JS, Reid RJ, Saravanan K, Willems HM, Lunec J. Hardcastle IR, et al. Among authors: ahmed su. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1515-20. doi: 10.1016/j.bmcl.2004.12.061. Bioorg Med Chem Lett. 2005. PMID: 15713419
Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency.
Hardcastle IR, Liu J, Valeur E, Watson A, Ahmed SU, Blackburn TJ, Bennaceur K, Clegg W, Drummond C, Endicott JA, Golding BT, Griffin RJ, Gruber J, Haggerty K, Harrington RW, Hutton C, Kemp S, Lu X, McDonnell JM, Newell DR, Noble ME, Payne SL, Revill CH, Riedinger C, Xu Q, Lunec J. Hardcastle IR, et al. Among authors: ahmed su. J Med Chem. 2011 Mar 10;54(5):1233-43. doi: 10.1021/jm1011929. Epub 2011 Feb 11. J Med Chem. 2011. PMID: 21314128
Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions†Electronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and intermediates. Details for the biological evaluation. Further details for the modeling. Table of combustion analysis data. See DOI: 10.1039/c3md00161jClick here for additional data file.
Blackburn TJ, Ahmed S, Coxon CR, Liu J, Lu X, Golding BT, Griffin RJ, Hutton C, Newell DR, Ojo S, Watson AF, Zaytzev A, Zhao Y, Lunec J, Hardcastle IR. Blackburn TJ, et al. Medchemcomm. 2013 Sep 21;4(9):1297-1304. doi: 10.1039/c3md00161j. Epub 2013 Jul 29. Medchemcomm. 2013. PMID: 24078862 Free PMC article.
Active-reset protein sensors enable continuous in vivo monitoring of inflammation.
Zargartalebi H, Mirzaie S, GhavamiNejad A, Ahmed SU, Esmaeili F, Geraili A, Flynn CD, Chang D, Das J, Abdrabou A, Sargent EH, Kelley SO. Zargartalebi H, et al. Among authors: ahmed su. Science. 2024 Dec 6;386(6726):1146-1153. doi: 10.1126/science.adn2600. Epub 2024 Dec 5. Science. 2024. PMID: 39636994
Identification of VISTA regulators in macrophages mediating cancer cell survival.
Abdrabou AM, Ahmed SU, Fan MJ, Duong BTV, Chen K, Lo PY, Mayes JM, Esmaeili F, GhavamiNejad A, Zargartalebi H, Atwal RS, Lin S, Angers S, Kelley SO. Abdrabou AM, et al. Among authors: ahmed su. Sci Adv. 2024 Nov 29;10(48):eadq8122. doi: 10.1126/sciadv.adq8122. Epub 2024 Nov 27. Sci Adv. 2024. PMID: 39602545 Free PMC article.
155 results