Nagarajan M - Search Results

1

Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles.

Nagarajan M, Morrell A, Ioanoviciu A, Antony S, Kohlhagen G, Agama K, Hollingshead M, Pommier Y, Cushman M. Nagarajan M, et al. J Med Chem. 2006 Oct 19;49(21):6283-9. doi: 10.1021/jm060564z. J Med Chem. 2006. PMID: 17034134 Free PMC article.

2

Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen.

Nagarajan M, Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M. Nagarajan M, et al. J Med Chem. 2003 Dec 18;46(26):5712-24. doi: 10.1021/jm030313f. J Med Chem. 2003. PMID: 14667224

3

Design, synthesis, anti-HIV activities, and metabolic stabilities of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors.

Silvestri MA, Nagarajan M, De Clercq E, Pannecouque C, Cushman M. Silvestri MA, et al. Among authors: nagarajan m. J Med Chem. 2004 Jun 3;47(12):3149-62. doi: 10.1021/jm049916x. J Med Chem. 2004. PMID: 15163195

4

Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings.

Nagarajan M, Morrell A, Fort BC, Meckley MR, Antony S, Kohlhagen G, Pommier Y, Cushman M. Nagarajan M, et al. J Med Chem. 2004 Nov 4;47(23):5651-61. doi: 10.1021/jm040025z. J Med Chem. 2004. PMID: 15509164

5

Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.

Morrell A, Jayaraman M, Nagarajan M, Fox BM, Meckley MR, Ioanoviciu A, Pommier Y, Antony S, Hollingshead M, Cushman M. Morrell A, et al. Among authors: nagarajan m. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4395-9. doi: 10.1016/j.bmcl.2006.05.048. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16750365

6

Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity.

Antony S, Agama KK, Miao ZH, Hollingshead M, Holbeck SL, Wright MH, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y. Antony S, et al. Among authors: nagarajan m. Mol Pharmacol. 2006 Sep;70(3):1109-20. doi: 10.1124/mol.106.024372. Epub 2006 Jun 23. Mol Pharmacol. 2006. PMID: 16798938

7

Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.

Nagarajan M, Morrell A, Antony S, Kohlhagen G, Agama K, Pommier Y, Ragazzon PA, Garbett NC, Chaires JB, Hollingshead M, Cushman M. Nagarajan M, et al. J Med Chem. 2006 Aug 24;49(17):5129-40. doi: 10.1021/jm060046o. J Med Chem. 2006. PMID: 16913702

8

Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance.

Antony S, Agama KK, Miao ZH, Takagi K, Wright MH, Robles AI, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y. Antony S, et al. Among authors: nagarajan m. Cancer Res. 2007 Nov 1;67(21):10397-405. doi: 10.1158/0008-5472.CAN-07-0938. Cancer Res. 2007. PMID: 17974983

9

10,10-Difluoro-13-dehydroprostacyclin: a chemically and metabolically stabilized potent prostacyclin.

Fried J, Mitra DK, Nagarajan M, Mehrotra MM. Fried J, et al. Among authors: nagarajan m. J Med Chem. 1980 Mar;23(3):234-7. doi: 10.1021/jm00177a003. J Med Chem. 1980. PMID: 6988588 No abstract available.

10

Transcriptomic Profiling Reveals Altered Expression of Genes Involved in Metabolic and Immune Processes in NDV-Infected Chicken Embryos.

Muthusamy M, Ramasamy KT, Peters SO, Palani S, Gowthaman V, Nagarajan M, Karuppusamy S, Thangavelu V, Aranganoor Kannan T. Muthusamy M, et al. Among authors: nagarajan m. Metabolites. 2024 Dec 2;14(12):669. doi: 10.3390/metabo14120669. Metabolites. 2024. PMID: 39728450 Free PMC article.

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