Zhang H - Search Results

1

Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar.

Zhang D, Wang L, Chandrasena G, Ma L, Zhu M, Zhang H, Davis CD, Humphreys WG. Zhang D, et al. Among authors: zhang h. Drug Metab Dispos. 2007 Jan;35(1):139-49. doi: 10.1124/dmd.106.011932. Epub 2006 Oct 24. Drug Metab Dispos. 2007. PMID: 17062778

2

Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys.

Zhang H, Zhang D, Li W, Yao M, D'Arienzo C, Li YX, Ewing WR, Gu Z, Zhu Y, Murugesan N, Shyu WC, Humphreys WG. Zhang H, et al. Among authors: zhang d. Drug Metab Dispos. 2007 May;35(5):795-805. doi: 10.1124/dmd.106.012781. Epub 2007 Feb 15. Drug Metab Dispos. 2007. PMID: 17303626

3

Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism.

Zhang D, Zhang D, Cui D, Gambardella J, Ma L, Barros A, Wang L, Fu Y, Rahematpura S, Nielsen J, Donegan M, Zhang H, Humphreys WG. Zhang D, et al. Among authors: zhang h. Drug Metab Dispos. 2007 Dec;35(12):2270-80. doi: 10.1124/dmd.107.017806. Epub 2007 Sep 26. Drug Metab Dispos. 2007. PMID: 17898154

4

Cytochrome P450 reaction-phenotyping: an industrial perspective.

Zhang H, Davis CD, Sinz MW, Rodrigues AD. Zhang H, et al. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):667-87. doi: 10.1517/17425255.3.5.667. Expert Opin Drug Metab Toxicol. 2007. PMID: 17916054 Review.

5

Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis.

Yao M, Zhu M, Sinz MW, Zhang H, Humphreys WG, Rodrigues AD, Dai R. Yao M, et al. Among authors: zhang h. J Pharm Biomed Anal. 2007 May 9;44(1):211-23. doi: 10.1016/j.jpba.2007.02.034. Epub 2007 Mar 3. J Pharm Biomed Anal. 2007. PMID: 17418993

6

Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism.

Gan J, Chen W, Shen H, Gao L, Hong Y, Tian Y, Li W, Zhang Y, Tang Y, Zhang H, Humphreys WG, Rodrigues AD. Gan J, et al. Among authors: zhang h, zhang y. Br J Clin Pharmacol. 2010 Dec;70(6):870-80. doi: 10.1111/j.1365-2125.2010.03772.x. Br J Clin Pharmacol. 2010. PMID: 21175442 Free PMC article.

7

Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro.

Chang SY, Li W, Traeger SC, Wang B, Cui D, Zhang H, Wen B, Rodrigues AD. Chang SY, et al. Among authors: zhang h. Drug Metab Dispos. 2008 Dec;36(12):2513-22. doi: 10.1124/dmd.108.022970. Epub 2008 Sep 11. Drug Metab Dispos. 2008. PMID: 18787056

8

Effect of commonly used organic solvents on the kinetics of cytochrome P450 2B6- and 2C8-dependent activity in human liver microsomes.

Vuppugalla R, Chang SY, Zhang H, Marathe PH, Rodrigues DA. Vuppugalla R, et al. Among authors: zhang h. Drug Metab Dispos. 2007 Nov;35(11):1990-5. doi: 10.1124/dmd.107.016816. Epub 2007 Aug 20. Drug Metab Dispos. 2007. PMID: 17709370

9

A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma.

Yao M, Zhang H, Chong S, Zhu M, Morrison RA. Yao M, et al. Among authors: zhang h. J Pharm Biomed Anal. 2003 Aug 21;32(6):1189-97. doi: 10.1016/s0731-7085(03)00050-5. J Pharm Biomed Anal. 2003. PMID: 12907263

10

(D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues.

Li J, Chen SY, Murphy BJ, Flynn N, Seethala R, Slusarchyk D, Yan M, Sleph P, Zhang H, Humphreys WG, Ewing WR, Robl JA, Gordon D, Tino JA. Li J, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4072-4. doi: 10.1016/j.bmcl.2008.05.100. Epub 2008 Jun 12. Bioorg Med Chem Lett. 2008. PMID: 18554903

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