Shiryaev SA - Search Results

1

Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses.

Shiryaev SA, Kozlov IA, Ratnikov BI, Smith JW, Lebl M, Strongin AY. Shiryaev SA, et al. Biochem J. 2007 Feb 1;401(3):743-52. doi: 10.1042/BJ20061136. Biochem J. 2007. PMID: 17067286 Free PMC article.

2

Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase.

Shiryaev SA, Ratnikov BI, Chekanov AV, Sikora S, Rozanov DV, Godzik A, Wang J, Smith JW, Huang Z, Lindberg I, Samuel MA, Diamond MS, Strongin AY. Shiryaev SA, et al. Biochem J. 2006 Jan 15;393(Pt 2):503-11. doi: 10.1042/BJ20051374. Biochem J. 2006. PMID: 16229682 Free PMC article.

3

Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region.

Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY. Shiryaev SA, et al. Protein Expr Purif. 2007 Apr;52(2):334-9. doi: 10.1016/j.pep.2006.11.009. Epub 2006 Dec 1. Protein Expr Purif. 2007. PMID: 17189703 Free PMC article.

4

Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis.

Shiryaev SA, Ratnikov BI, Aleshin AE, Kozlov IA, Nelson NA, Lebl M, Smith JW, Liddington RC, Strongin AY. Shiryaev SA, et al. J Virol. 2007 May;81(9):4501-9. doi: 10.1128/JVI.02719-06. Epub 2007 Feb 14. J Virol. 2007. PMID: 17301157 Free PMC article.

5

Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold.

Aleshin AE, Shiryaev SA, Strongin AY, Liddington RC. Aleshin AE, et al. Among authors: shiryaev sa. Protein Sci. 2007 May;16(5):795-806. doi: 10.1110/ps.072753207. Epub 2007 Mar 30. Protein Sci. 2007. PMID: 17400917 Free PMC article.

6

Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.

Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY. Shiryaev SA, et al. J Biol Chem. 2007 Jul 20;282(29):20847-53. doi: 10.1074/jbc.M703847200. Epub 2007 May 30. J Biol Chem. 2007. PMID: 17537721 Free article.

7

Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.

Golubkov VS, Chekanov AV, Shiryaev SA, Aleshin AE, Ratnikov BI, Gawlik K, Radichev I, Motamedchaboki K, Smith JW, Strongin AY. Golubkov VS, et al. Among authors: shiryaev sa. J Biol Chem. 2007 Dec 14;282(50):36283-91. doi: 10.1074/jbc.M706290200. Epub 2007 Oct 15. J Biol Chem. 2007. PMID: 17938169 Free article.

8

Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism.

D'Alessio S, Ferrari G, Cinnante K, Scheerer W, Galloway AC, Roses DF, Rozanov DV, Remacle AG, Oh ES, Shiryaev SA, Strongin AY, Pintucci G, Mignatti P. D'Alessio S, et al. Among authors: shiryaev sa. J Biol Chem. 2008 Jan 4;283(1):87-99. doi: 10.1074/jbc.M705492200. Epub 2007 Nov 8. J Biol Chem. 2008. PMID: 17991754 Free article.

9

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus.

Johnston PA, Phillips J, Shun TY, Shinde S, Lazo JS, Huryn DM, Myers MC, Ratnikov BI, Smith JW, Su Y, Dahl R, Cosford ND, Shiryaev SA, Strongin AY. Johnston PA, et al. Among authors: shiryaev sa. Assay Drug Dev Technol. 2007 Dec;5(6):737-50. doi: 10.1089/adt.2007.101. Assay Drug Dev Technol. 2007. PMID: 18181690

10

Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase.

Radichev I, Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY. Radichev I, et al. Among authors: shiryaev sa. J Gen Virol. 2008 Mar;89(Pt 3):636-641. doi: 10.1099/vir.0.83359-0. J Gen Virol. 2008. PMID: 18272753

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