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Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells.
Williams TM, Sotgia F, Lee H, Hassan G, Di Vizio D, Bonuccelli G, Capozza F, Mercier I, Rui H, Pestell RG, Lisanti MP. Williams TM, et al. Among authors: lee h. Am J Pathol. 2006 Nov;169(5):1784-801. doi: 10.2353/ajpath.2006.060590. Am J Pathol. 2006. PMID: 17071600 Free PMC article.
Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment.
Iyengar P, Espina V, Williams TW, Lin Y, Berry D, Jelicks LA, Lee H, Temple K, Graves R, Pollard J, Chopra N, Russell RG, Sasisekharan R, Trock BJ, Lippman M, Calvert VS, Petricoin EF 3rd, Liotta L, Dadachova E, Pestell RG, Lisanti MP, Bonaldo P, Scherer PE. Iyengar P, et al. Among authors: lee h. J Clin Invest. 2005 May;115(5):1163-76. doi: 10.1172/JCI23424. Epub 2005 Apr 14. J Clin Invest. 2005. PMID: 15841211 Free PMC article.
Caveolin-1 null (-/-) mice show dramatic reductions in life span.
Park DS, Cohen AW, Frank PG, Razani B, Lee H, Williams TM, Chandra M, Shirani J, De Souza AP, Tang B, Jelicks LA, Factor SM, Weiss LM, Tanowitz HB, Lisanti MP. Park DS, et al. Among authors: lee h. Biochemistry. 2003 Dec 30;42(51):15124-31. doi: 10.1021/bi0356348. Biochemistry. 2003. PMID: 14690422
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