Holloway GA - Search Results

1

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.

Holloway GA, Baell JB, Fairlamb AH, Novello PM, Parisot JP, Richardson J, Watson KG, Street IP. Holloway GA, et al. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1422-7. doi: 10.1016/j.bmcl.2006.11.090. Epub 2006 Dec 3. Bioorg Med Chem Lett. 2007. PMID: 17194585 Free PMC article.

2

Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.

Holloway GA, Parisot JP, Novello PM, Watson KG, Armstrong T, Thompson RC, Street IP, Baell JB. Holloway GA, et al. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1816-8. doi: 10.1016/j.bmcl.2010.02.022. Epub 2010 Feb 8. Bioorg Med Chem Lett. 2010. PMID: 20185305 Free article.

3

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.

Holloway GA, Charman WN, Fairlamb AH, Brun R, Kaiser M, Kostewicz E, Novello PM, Parisot JP, Richardson J, Street IP, Watson KG, Baell JB. Holloway GA, et al. Antimicrob Agents Chemother. 2009 Jul;53(7):2824-33. doi: 10.1128/AAC.01568-08. Epub 2009 Apr 13. Antimicrob Agents Chemother. 2009. PMID: 19364854 Free PMC article.

4

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays.

Baell JB, Holloway GA. Baell JB, et al. Among authors: holloway ga. J Med Chem. 2010 Apr 8;53(7):2719-40. doi: 10.1021/jm901137j. J Med Chem. 2010. PMID: 20131845

5

Dimeric cyclohexane-1,3-dione oximes inhibit wheat acetyl-CoA carboxylase and show anti-malarial activity.

Louie T, Goodman CD, Holloway GA, McFadden GI, Mollard V, Watson KG. Louie T, et al. Among authors: holloway ga. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4611-3. doi: 10.1016/j.bmcl.2010.06.007. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20580556

6

Apicoplast acetyl Co-A carboxylase of the human malaria parasite is not targeted by cyclohexanedione herbicides.

Goodman CD, Mollard V, Louie T, Holloway GA, Watson KG, McFadden GI. Goodman CD, et al. Among authors: holloway ga. Int J Parasitol. 2014 Apr;44(5):285-9. doi: 10.1016/j.ijpara.2014.01.007. Epub 2014 Feb 25. Int J Parasitol. 2014. PMID: 24583112 Free article.

7

Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.

Adams TE, El Sous M, Hawkins BC, Hirner S, Holloway G, Khoo ML, Owen DJ, Savage GP, Scammells PJ, Rizzacasa MA. Adams TE, et al. J Am Chem Soc. 2009 Feb 4;131(4):1607-16. doi: 10.1021/ja808402e. J Am Chem Soc. 2009. PMID: 19140688

8

Formal total synthesis of salicylihalamides A and B.

Holloway GA, Hügel HM, Rizzacasa MA. Holloway GA, et al. J Org Chem. 2003 Mar 21;68(6):2200-4. doi: 10.1021/jo026798h. J Org Chem. 2003. PMID: 12636381

9

Total synthesis of (-)-episilvestrol and (-)-silvestrol.

El Sous M, Khoo ML, Holloway G, Owen D, Scammells PJ, Rizzacasa MA. El Sous M, et al. Angew Chem Int Ed Engl. 2007;46(41):7835-8. doi: 10.1002/anie.200702700. Angew Chem Int Ed Engl. 2007. PMID: 17823902 No abstract available.

10

The effect of pressure loading on the blood flow rate in human skin.

Daly CH, Chimoskey JE, Holloway GA, Kennedy D. Daly CH, et al. Among authors: holloway ga. J Tissue Viability. 2006 Nov;16(4):17-21. doi: 10.1016/s0965-206x(06)64004-7. J Tissue Viability. 2006. PMID: 17153119

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