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Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice.
Denton CP, Zheng B, Evans LA, Shi-wen X, Ong VH, Fisher I, Lazaridis K, Abraham DJ, Black CM, de Crombrugghe B. Denton CP, et al. J Biol Chem. 2003 Jul 4;278(27):25109-19. doi: 10.1074/jbc.M300636200. Epub 2003 Apr 21. J Biol Chem. 2003. PMID: 12707256 Free article.
Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.
Chen Y, Leask A, Abraham DJ, Pala D, Shiwen X, Khan K, Liu S, Carter DE, Wilcox-Adelman S, Goetinck P, Denton CP, Black CM, Pitsillides AA, Sarraf CE, Eastwood M. Chen Y, et al. Among authors: denton cp. Arthritis Rheum. 2008 Feb;58(2):577-85. doi: 10.1002/art.23146. Arthritis Rheum. 2008. PMID: 18240216 Free article.
Fibroblast-specific perturbation of transforming growth factor beta signaling provides insight into potential pathogenic mechanisms of scleroderma-associated lung fibrosis: exaggerated response to alveolar epithelial injury in a novel mouse model.
Hoyles RK, Khan K, Shiwen X, Howat SL, Lindahl GE, Leoni P, du Bois RM, Wells AU, Black CM, Abraham DJ, Denton CP. Hoyles RK, et al. Among authors: denton cp. Arthritis Rheum. 2008 Apr;58(4):1175-88. doi: 10.1002/art.23379. Arthritis Rheum. 2008. PMID: 18383385 Free article.
543 results