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Page 1
Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039).
Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, Nisenbaum ES, Catlow JT, Kingston AE, Giera DD, Herin MF, Monn JA, McKinzie DL, Schoepp DD. Rorick-Kehn LM, et al. Among authors: burkey jl. J Pharmacol Exp Ther. 2007 Apr;321(1):308-17. doi: 10.1124/jpet.106.110809. Epub 2007 Jan 4. J Pharmacol Exp Ther. 2007. PMID: 17204749
In vivo metabolism of [14C]ruboxistaurin in dogs, mice, and rats following oral administration and the structure determination of its metabolites by liquid chromatography/mass spectrometry and NMR spectroscopy.
Barbuch RJ, Campanale K, Hadden CE, Zmijewski M, Yi P, O'Bannon DD, Burkey JL, Kulanthaivel P. Barbuch RJ, et al. Among authors: burkey jl. Drug Metab Dispos. 2006 Feb;34(2):213-24. doi: 10.1124/dmd.105.007401. Epub 2005 Oct 28. Drug Metab Dispos. 2006. PMID: 16258078
Disposition of [14C]ruboxistaurin in humans.
Burkey JL, Campanale KM, Barbuch R, O'Bannon D, Rash J, Benson C, Small D. Burkey JL, et al. Drug Metab Dispos. 2006 Nov;34(11):1909-17. doi: 10.1124/dmd.106.009894. Epub 2006 Aug 8. Drug Metab Dispos. 2006. PMID: 16896067 Clinical Trial.