Shokat KM - Search Results

1

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3.

Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat KM, Moasser MM. Sergina NV, et al. Among authors: shokat km. Nature. 2007 Jan 25;445(7126):437-41. doi: 10.1038/nature05474. Epub 2007 Jan 7. Nature. 2007. PMID: 17206155 Free PMC article.

2

Targets of the cyclin-dependent kinase Cdk1.

Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. Ubersax JA, et al. Among authors: shokat km. Nature. 2003 Oct 23;425(6960):859-64. doi: 10.1038/nature02062. Nature. 2003. PMID: 14574415

3

Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.

Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA. Fan QW, et al. Among authors: shokat km. Cancer Res. 2003 Dec 15;63(24):8930-8. Cancer Res. 2003. PMID: 14695210

4

Small-molecule kinase-inhibitor target assessment.

Kung C, Shokat KM. Kung C, et al. Among authors: shokat km. Chembiochem. 2005 Mar;6(3):523-6. doi: 10.1002/cbic.200400393. Chembiochem. 2005. PMID: 15696508

5

A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases.

Zhang C, Kenski DM, Paulson JL, Bonshtien A, Sessa G, Cross JV, Templeton DJ, Shokat KM. Zhang C, et al. Among authors: shokat km. Nat Methods. 2005 Jun;2(6):435-41. doi: 10.1038/nmeth764. Nat Methods. 2005. PMID: 15908922

6

Selective kinase inhibition by exploiting differential pathway sensitivity.

Kung C, Kenski DM, Krukenberg K, Madhani HD, Shokat KM. Kung C, et al. Among authors: shokat km. Chem Biol. 2006 Apr;13(4):399-407. doi: 10.1016/j.chembiol.2006.02.004. Chem Biol. 2006. PMID: 16632252 Free PMC article.

7

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.

Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA. Fan QW, et al. Among authors: shokat km. Cancer Cell. 2006 May;9(5):341-9. doi: 10.1016/j.ccr.2006.03.029. Cancer Cell. 2006. PMID: 16697955 Free PMC article.

8

Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.

Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM. Blair JA, et al. Among authors: shokat km. Nat Chem Biol. 2007 Apr;3(4):229-38. doi: 10.1038/nchembio866. Epub 2007 Mar 4. Nat Chem Biol. 2007. PMID: 17334377

9

Chemically targeting the PI3K family.

Knight ZA, Shokat KM. Knight ZA, et al. Among authors: shokat km. Biochem Soc Trans. 2007 Apr;35(Pt 2):245-9. doi: 10.1042/BST0350245. Biochem Soc Trans. 2007. PMID: 17371250

10

A semisynthetic epitope for kinase substrates.

Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat KM. Allen JJ, et al. Among authors: shokat km. Nat Methods. 2007 Jun;4(6):511-6. doi: 10.1038/nmeth1048. Epub 2007 May 7. Nat Methods. 2007. PMID: 17486086 Free PMC article.

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