Greig IR - Search Results

1

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.

Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Greig IR, Vocadlo DJ. Whitworth GE, et al. Among authors: greig ir. J Am Chem Soc. 2007 Jan 24;129(3):635-44. doi: 10.1021/ja065697o. J Am Chem Soc. 2007. PMID: 17227027

2

Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships.

Greig IR, Macauley MS, Williams IH, Vocadlo DJ. Greig IR, et al. J Am Chem Soc. 2009 Sep 23;131(37):13415-22. doi: 10.1021/ja904506u. J Am Chem Soc. 2009. PMID: 19715310

3

Structural, mechanistic, and computational analysis of the effects of anomeric fluorines on anomeric fluoride departure in 5-fluoroxylosyl fluorides.

Lee SS, Greig IR, Vocadlo DJ, McCarter JD, Patrick BO, Withers SG. Lee SS, et al. Among authors: greig ir. J Am Chem Soc. 2011 Oct 12;133(40):15826-9. doi: 10.1021/ja204829r. Epub 2011 Sep 19. J Am Chem Soc. 2011. PMID: 21910446

4

Elucidating the nature of the Streptomyces plicatus beta-hexosaminidase-bound intermediate using ab initio molecular dynamics simulations.

Greig IR, Zahariev F, Withers SG. Greig IR, et al. J Am Chem Soc. 2008 Dec 24;130(51):17620-8. doi: 10.1021/ja805640c. J Am Chem Soc. 2008. PMID: 19053474

5

Remarkable Reactivity Differences between Glucosides with Identical Leaving Groups.

Duo T, Robinson K, Greig IR, Chen HM, Patrick BO, Withers SG. Duo T, et al. Among authors: greig ir. J Am Chem Soc. 2017 Nov 8;139(44):15994-15999. doi: 10.1021/jacs.7b09645. Epub 2017 Oct 24. J Am Chem Soc. 2017. PMID: 29035043

6

Tuning mechanism-based inactivators of neuraminidases: mechanistic and structural insights.

Buchini S, Gallat FX, Greig IR, Kim JH, Wakatsuki S, Chavas LM, Withers SG. Buchini S, et al. Among authors: greig ir. Angew Chem Int Ed Engl. 2014 Mar 24;53(13):3382-6. doi: 10.1002/anie.201309675. Epub 2014 Mar 3. Angew Chem Int Ed Engl. 2014. PMID: 24591206

7

The analysis of enzymic free energy relationships using kinetic and computational models.

Greig IR. Greig IR. Chem Soc Rev. 2010 Jun;39(6):2272-301. doi: 10.1039/b902741f. Epub 2010 Apr 23. Chem Soc Rev. 2010. PMID: 20419174 Review.

8

Glycosidase inhibitors as conformational transition state analogues.

Greig IR, Williams IH. Greig IR, et al. Chem Commun (Camb). 2007 Sep 28;(36):3747-9. doi: 10.1039/b705607a. Epub 2007 Jun 28. Chem Commun (Camb). 2007. PMID: 17851615

9

Mechanism of glycoside hydrolysis: A comparative QM/MM molecular dynamics analysis for wild type and Y69F mutant retaining xylanases.

Soliman ME, Pernía JJ, Greig IR, Williams IH. Soliman ME, et al. Among authors: greig ir. Org Biomol Chem. 2009 Dec 21;7(24):5236-44. doi: 10.1039/b911644c. Epub 2009 Oct 22. Org Biomol Chem. 2009. PMID: 20024120

10

Computational mutagenesis reveals the role of active-site tyrosine in stabilising a boat conformation for the substrate: QM/MM molecular dynamics studies of wild-type and mutant xylanases.

Soliman ME, Ruggiero GD, Pernía JJ, Greig IR, Williams IH. Soliman ME, et al. Among authors: greig ir. Org Biomol Chem. 2009 Feb 7;7(3):460-8. doi: 10.1039/b814695k. Epub 2008 Dec 5. Org Biomol Chem. 2009. PMID: 19156310 Free article.

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