Greene GL - Search Results

1

Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.

Zhou HB, Sheng S, Compton DR, Kim Y, Joachimiak A, Sharma S, Carlson KE, Katzenellenbogen BS, Nettles KW, Greene GL, Katzenellenbogen JA. Zhou HB, et al. Among authors: greene gl. J Med Chem. 2007 Jan 25;50(2):399-403. doi: 10.1021/jm061035y. J Med Chem. 2007. PMID: 17228884

2

Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands.

Zhou HB, Nettles KW, Bruning JB, Kim Y, Joachimiak A, Sharma S, Carlson KE, Stossi F, Katzenellenbogen BS, Greene GL, Katzenellenbogen JA. Zhou HB, et al. Among authors: greene gl. Chem Biol. 2007 Jun;14(6):659-69. doi: 10.1016/j.chembiol.2007.04.009. Chem Biol. 2007. PMID: 17584613

3

Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain.

Sharma A, Toy W, Guillen VS, Sharma N, Min J, Carlson KE, Mayne CG, Lin S, Sabio M, Greene G, Katzenellenbogen BS, Chandarlapaty S, Katzenellenbogen JA. Sharma A, et al. ACS Chem Biol. 2018 Dec 21;13(12):3374-3384. doi: 10.1021/acschembio.8b00877. Epub 2018 Nov 26. ACS Chem Biol. 2018. PMID: 30404440 Free PMC article.

4

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.

Shiau AK, Barstad D, Radek JT, Meyers MJ, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA, Agard DA, Greene GL. Shiau AK, et al. Among authors: greene gl. Nat Struct Biol. 2002 May;9(5):359-64. doi: 10.1038/nsb787. Nat Struct Biol. 2002. PMID: 11953755

5

Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors.

Nettles KW, Sun J, Radek JT, Sheng S, Rodriguez AL, Katzenellenbogen JA, Katzenellenbogen BS, Greene GL. Nettles KW, et al. Among authors: greene gl. Mol Cell. 2004 Feb 13;13(3):317-27. doi: 10.1016/s1097-2765(04)00054-1. Mol Cell. 2004. PMID: 14967140 Free article.

6

Structural plasticity in the oestrogen receptor ligand-binding domain.

Nettles KW, Bruning JB, Gil G, O'Neill EE, Nowak J, Guo Y, Kim Y, DeSombre ER, Dilis R, Hanson RN, Joachimiak A, Greene GL. Nettles KW, et al. Among authors: greene gl. EMBO Rep. 2007 Jun;8(6):563-8. doi: 10.1038/sj.embor.7400963. Epub 2007 Apr 27. EMBO Rep. 2007. PMID: 17468738 Free PMC article.

7

NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.

Nettles KW, Bruning JB, Gil G, Nowak J, Sharma SK, Hahm JB, Kulp K, Hochberg RB, Zhou H, Katzenellenbogen JA, Katzenellenbogen BS, Kim Y, Joachmiak A, Greene GL. Nettles KW, et al. Among authors: greene gl. Nat Chem Biol. 2008 Apr;4(4):241-7. doi: 10.1038/nchembio.76. Epub 2008 Mar 16. Nat Chem Biol. 2008. PMID: 18344977 Free PMC article.

8

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation.

Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF. Abot A, et al. Among authors: greene gl. EMBO Mol Med. 2014 Oct;6(10):1328-46. doi: 10.15252/emmm.201404112. EMBO Mol Med. 2014. PMID: 25214462 Free PMC article.

9

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.

Fanning SW, Mayne CG, Dharmarajan V, Carlson KE, Martin TA, Novick SJ, Toy W, Green B, Panchamukhi S, Katzenellenbogen BS, Tajkhorshid E, Griffin PR, Shen Y, Chandarlapaty S, Katzenellenbogen JA, Greene GL. Fanning SW, et al. Among authors: greene gl. Elife. 2016 Feb 2;5:e12792. doi: 10.7554/eLife.12792. Elife. 2016. PMID: 26836308 Free PMC article.

10

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.

Katzenellenbogen JA, Mayne CG, Katzenellenbogen BS, Greene GL, Chandarlapaty S. Katzenellenbogen JA, et al. Among authors: greene gl. Nat Rev Cancer. 2018 Jun;18(6):377-388. doi: 10.1038/s41568-018-0001-z. Nat Rev Cancer. 2018. PMID: 29662238 Free PMC article. Review.

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