Sheng S - Search Results

1

Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.

Zhou HB, Sheng S, Compton DR, Kim Y, Joachimiak A, Sharma S, Carlson KE, Katzenellenbogen BS, Nettles KW, Greene GL, Katzenellenbogen JA. Zhou HB, et al. Among authors: sheng s. J Med Chem. 2007 Jan 25;50(2):399-403. doi: 10.1021/jm061035y. J Med Chem. 2007. PMID: 17228884

2

Antagonists selective for estrogen receptor alpha.

Sun J, Huang YR, Harrington WR, Sheng S, Katzenellenbogen JA, Katzenellenbogen BS. Sun J, et al. Among authors: sheng s. Endocrinology. 2002 Mar;143(3):941-7. doi: 10.1210/endo.143.3.8704. Endocrinology. 2002. PMID: 11861516

3

Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.

Muthyala RS, Sheng S, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA. Muthyala RS, et al. Among authors: sheng s. J Med Chem. 2003 Apr 24;46(9):1589-602. doi: 10.1021/jm0204800. J Med Chem. 2003. PMID: 12699377

4

Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression.

Harrington WR, Sheng S, Barnett DH, Petz LN, Katzenellenbogen JA, Katzenellenbogen BS. Harrington WR, et al. Among authors: sheng s. Mol Cell Endocrinol. 2003 Aug 29;206(1-2):13-22. doi: 10.1016/s0303-7207(03)00255-7. Mol Cell Endocrinol. 2003. PMID: 12943986

5

Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process.

Minutolo F, Antonello M, Bertini S, Ortore G, Placanica G, Rapposelli S, Sheng S, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA, Macchia M. Minutolo F, et al. Among authors: sheng s. J Med Chem. 2003 Sep 11;46(19):4032-42. doi: 10.1021/jm0308390. J Med Chem. 2003. PMID: 12954056

6

Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta.

Muthyala RS, Ju YH, Sheng S, Williams LD, Doerge DR, Katzenellenbogen BS, Helferich WG, Katzenellenbogen JA. Muthyala RS, et al. Among authors: sheng s. Bioorg Med Chem. 2004 Mar 15;12(6):1559-67. doi: 10.1016/j.bmc.2003.11.035. Bioorg Med Chem. 2004. PMID: 15018930

7

Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity.

Compton DR, Sheng S, Carlson KE, Rebacz NA, Lee IY, Katzenellenbogen BS, Katzenellenbogen JA. Compton DR, et al. Among authors: sheng s. J Med Chem. 2004 Nov 18;47(24):5872-93. doi: 10.1021/jm049631k. J Med Chem. 2004. PMID: 15537344

8

Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-substituted 3,4-diarylsalicylaldoximes on estrogen receptors alpha and beta.

Minutolo F, Antonello M, Bertini S, Rapposelli S, Rossello A, Sheng S, Carlson KE, Katzenellenbogen JA, Macchia M. Minutolo F, et al. Among authors: sheng s. Bioorg Med Chem. 2003 Apr 3;11(7):1247-57. doi: 10.1016/s0968-0896(02)00640-5. Bioorg Med Chem. 2003. PMID: 12628652

9

Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors.

Nettles KW, Sun J, Radek JT, Sheng S, Rodriguez AL, Katzenellenbogen JA, Katzenellenbogen BS, Greene GL. Nettles KW, et al. Among authors: sheng s. Mol Cell. 2004 Feb 13;13(3):317-27. doi: 10.1016/s1097-2765(04)00054-1. Mol Cell. 2004. PMID: 14967140 Free article.

10

Differential estradiol and selective estrogen receptor modulator (SERM) regulation of Keratin 13 gene expression and its underlying mechanism in breast cancer cells.

Sheng S, Barnett DH, Katzenellenbogen BS. Sheng S, et al. Mol Cell Endocrinol. 2008 Dec 16;296(1-2):1-9. doi: 10.1016/j.mce.2008.09.022. Epub 2008 Oct 4. Mol Cell Endocrinol. 2008. PMID: 18951949 Free PMC article.

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