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In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.
De Keersmaecker K, Lahortiga I, Mentens N, Folens C, Van Neste L, Bekaert S, Vandenberghe P, Odero MD, Marynen P, Cools J. De Keersmaecker K, et al. Among authors: lahortiga i. Haematologica. 2008 Apr;93(4):533-42. doi: 10.3324/haematol.11894. Epub 2008 Mar 5. Haematologica. 2008. PMID: 18322257 Free article.
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.
Lahortiga I, De Keersmaecker K, Van Vlierberghe P, Graux C, Cauwelier B, Lambert F, Mentens N, Beverloo HB, Pieters R, Speleman F, Odero MD, Bauters M, Froyen G, Marynen P, Vandenberghe P, Wlodarska I, Meijerink JP, Cools J. Lahortiga I, et al. Nat Genet. 2007 May;39(5):593-5. doi: 10.1038/ng2025. Epub 2007 Apr 15. Nat Genet. 2007. PMID: 17435759
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.
Kleppe M, Lahortiga I, El Chaar T, De Keersmaecker K, Mentens N, Graux C, Van Roosbroeck K, Ferrando AA, Langerak AW, Meijerink JP, Sigaux F, Haferlach T, Wlodarska I, Vandenberghe P, Soulier J, Cools J. Kleppe M, et al. Among authors: lahortiga i. Nat Genet. 2010 Jun;42(6):530-5. doi: 10.1038/ng.587. Epub 2010 May 16. Nat Genet. 2010. PMID: 20473312 Free PMC article.
Identification of novel FLT3 kinase inhibitors.
Pauwels D, Klaassen H, Lahortiga I, Kilonda A, Jacobs K, Sweron B, Corbau R, Chaltin P, Marchand A, Cools J. Pauwels D, et al. Among authors: lahortiga i. Eur J Med Chem. 2013 May;63:713-21. doi: 10.1016/j.ejmech.2013.03.024. Epub 2013 Mar 21. Eur J Med Chem. 2013. PMID: 23567961
Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia.
Vicente C, Schwab C, Broux M, Geerdens E, Degryse S, Demeyer S, Lahortiga I, Elliott A, Chilton L, La Starza R, Mecucci C, Vandenberghe P, Goulden N, Vora A, Moorman AV, Soulier J, Harrison CJ, Clappier E, Cools J. Vicente C, et al. Among authors: lahortiga i. Haematologica. 2015 Oct;100(10):1301-10. doi: 10.3324/haematol.2015.130179. Epub 2015 Jul 23. Haematologica. 2015. PMID: 26206799 Free PMC article.
45 results