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Page 1
Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase.
Cee VJ, Albrecht BK, Geuns-Meyer S, Hughes P, Bellon S, Bready J, Caenepeel S, Chaffee SC, Coxon A, Emery M, Fretland J, Gallant P, Gu Y, Hodous BL, Hoffman D, Johnson RE, Kendall R, Kim JL, Long AM, McGowan D, Morrison M, Olivieri PR, Patel VF, Polverino A, Powers D, Rose P, Wang L, Zhao H. Cee VJ, et al. Among authors: hoffman d. J Med Chem. 2007 Feb 22;50(4):627-40. doi: 10.1021/jm061112p. Epub 2007 Jan 25. J Med Chem. 2007. PMID: 17253679
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
Hodous BL, Geuns-Meyer SD, Hughes PE, Albrecht BK, Bellon S, Bready J, Caenepeel S, Cee VJ, Chaffee SC, Coxon A, Emery M, Fretland J, Gallant P, Gu Y, Hoffman D, Johnson RE, Kendall R, Kim JL, Long AM, Morrison M, Olivieri PR, Patel VF, Polverino A, Rose P, Tempest P, Wang L, Whittington DA, Zhao H. Hodous BL, et al. Among authors: hoffman d. J Med Chem. 2007 Feb 22;50(4):611-26. doi: 10.1021/jm061107l. Epub 2007 Jan 25. J Med Chem. 2007. PMID: 17253678
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.
Albrecht BK, Harmange JC, Bauer D, Berry L, Bode C, Boezio AA, Chen A, Choquette D, Dussault I, Fridrich C, Hirai S, Hoffman D, Larrow JF, Kaplan-Lefko P, Lin J, Lohman J, Long AM, Moriguchi J, O'Connor A, Potashman MH, Reese M, Rex K, Siegmund A, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Bellon SF. Albrecht BK, et al. Among authors: hoffman d. J Med Chem. 2008 May 22;51(10):2879-82. doi: 10.1021/jm800043g. Epub 2008 Apr 22. J Med Chem. 2008. PMID: 18426196
Second-generation peptidomimetic inhibitors of protein farnesyltransferase demonstrating improved cellular potency and significant in vivo efficacy.
O'Connor SJ, Barr KJ, Wang L, Sorensen BK, Tasker AS, Sham H, Ng SC, Cohen J, Devine E, Cherian S, Saeed B, Zhang H, Lee JY, Warner R, Tahir S, Kovar P, Ewing P, Alder J, Mitten M, Leal J, Marsh K, Bauch J, Hoffman DJ, Sebti SM, Rosenberg SH. O'Connor SJ, et al. Among authors: hoffman dj. J Med Chem. 1999 Sep 9;42(18):3701-10. doi: 10.1021/jm9901935. J Med Chem. 1999. PMID: 10479301
Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake.
Bajunaid R, Niu C, Hambly C, Liu Z, Yamada Y, Aleman-Mateo H, Anderson LJ, Arab L, Baddou I, Bandini L, Bedu-Addo K, Blaak EE, Bouten CVC, Brage S, Buchowski MS, Butte NF, Camps SGJA, Casper R, Close GL, Cooper JA, Cooper R, Das SK, Davies PSW, Dabare P, Dugas LR, Eaton S, Ekelund U, Entringer S, Forrester T, Fudge BW, Gillingham M, Goris AH, Gurven M, El Hamdouchi A, Haisma HH, Hoffman D, Hoos MB, Hu S, Joonas N, Joosen AM, Katzmarzyk P, Kimura M, Kraus WE, Kriengsinyos W, Kuriyan R, Kushner RF, Lambert EV, Lanerolle P, Larsson CL, Leonard WR, Lessan N, Löf M, Martin CK, Matsiko E, Medin AC, Morehen JC, Morton JP, Must A, Neuhouser ML, Nicklas TA, Nyström CD, Ojiambo RM, Pietiläinen KH, Pitsiladis YP, Plange-Rhule J, Plasqui G, Prentice RL, Racette SB, Raichlen DA, Ravussin E, Redman LM, Reilly JJ, Reynolds R, Roberts SB, Samaranayakem D, Sardinha LB, Silva AM, Sjödin AM, Stamatiou M, Stice E, Urlacher SS, Van Etten LM, van Mil EGAH, Wilson G, Yanovski JA, Yoshida T, Zhang X, Murphy-Alford AJ, Sinha S, Loechl CU, Luke AH, Pontzer H, Rood J, Sagayama H, Schoeller DA, Westerterp KR, Wong WW, Speakman JR. Bajunaid R, et al. Among authors: hoffman d. Nat Food. 2025 Jan 13. doi: 10.1038/s43016-024-01089-5. Online ahead of print. Nat Food. 2025. PMID: 39806218
Results from a phase 1b study of telisotuzumab vedotin in combination with osimertinib in patients with c-Met protein-overexpressing, EGFR-mutated locally advanced/metastatic non-small cell lung cancer (NSCLC) after progression on prior osimertinib.
Horinouchi H, Cho BC, Camidge DR, Goto K, Tomasini P, Li Y, Vasilopoulos A, Brunsdon P, Hoffman D, Shi W, Bolotin E, Blot V, Goldman J. Horinouchi H, et al. Among authors: hoffman d. Ann Oncol. 2025 Jan 11:S0923-7534(25)00005-5. doi: 10.1016/j.annonc.2025.01.001. Online ahead of print. Ann Oncol. 2025. PMID: 39805351
1,688 results