Iley J - Search Results

1

Crystallization and preliminary diffraction studies of porcine pancreatic elastase in complex with a novel inhibitor.

Oliveira TF, Mulchande J, Moreira R, Iley J, Archer M. Oliveira TF, et al. Among authors: iley j. Protein Pept Lett. 2007;14(1):93-5. doi: 10.2174/092986607779117173. Protein Pept Lett. 2007. PMID: 17266656

2

The efficiency of C-4 substituents in activating the beta-lactam scaffold towards serine proteases and hydroxide ion.

Mulchande J, Martins L, Moreira R, Archer M, Oliveira TF, Iley J. Mulchande J, et al. Among authors: iley j. Org Biomol Chem. 2007 Aug 21;5(16):2617-26. doi: 10.1039/b706622h. Org Biomol Chem. 2007. PMID: 18019537

3

Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors.

Mulchande J, Guedes RC, Tsang WY, Page MI, Moreira R, Iley J. Mulchande J, et al. Among authors: iley j. J Med Chem. 2008 Mar 27;51(6):1783-90. doi: 10.1021/jm701257h. Epub 2008 Feb 22. J Med Chem. 2008. PMID: 18290604

4

Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase.

Moreira R, Santana AB, Iley J, Neres J, Douglas KT, Horton PN, Hursthouse MB. Moreira R, et al. Among authors: iley j. J Med Chem. 2005 Jul 28;48(15):4861-70. doi: 10.1021/jm0501331. J Med Chem. 2005. PMID: 16033266

5

4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

Mulchande J, Oliveira R, Carrasco M, Gouveia L, Guedes RC, Iley J, Moreira R. Mulchande J, et al. Among authors: iley j. J Med Chem. 2010 Jan 14;53(1):241-53. doi: 10.1021/jm901082k. J Med Chem. 2010. PMID: 19904934

6

Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase.

Mulchande J, Simões SI, Gaspar MM, Eleutério CV, Oliveira R, Cruz ME, Moreira R, Iley J. Mulchande J, et al. Among authors: iley j. J Enzyme Inhib Med Chem. 2011 Apr;26(2):169-75. doi: 10.3109/14756366.2010.486794. Epub 2010 Jun 14. J Enzyme Inhib Med Chem. 2011. PMID: 20545486 Free article.

7

N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases.

Santana AB, Lucas SD, Gonçalves LM, Correia HF, Cardote TA, Guedes RC, Iley J, Moreira R. Santana AB, et al. Among authors: iley j. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3993-7. doi: 10.1016/j.bmcl.2012.04.093. Epub 2012 Apr 28. Bioorg Med Chem Lett. 2012. PMID: 22595175

8

The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors.

Valente C, Moreira R, Guedes RC, Iley J, Jaffar M, Douglas KT. Valente C, et al. Among authors: iley j. Bioorg Med Chem. 2007 Aug 1;15(15):5340-50. doi: 10.1016/j.bmc.2007.04.068. Epub 2007 May 6. Bioorg Med Chem. 2007. PMID: 17532221

9

Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one.

Valente E, Gomes JR, Moreira R, Iley J. Valente E, et al. Among authors: iley j. J Org Chem. 2004 May 14;69(10):3359-67. doi: 10.1021/jo0358123. J Org Chem. 2004. PMID: 15132543

10

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors.

Clemente A, Domingos A, Grancho AP, Iley J, Moreira R, Neres J, Palma N, Santana AB, Valente E. Clemente A, et al. Among authors: iley j. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1065-8. doi: 10.1016/s0960-894x(01)00131-7. Bioorg Med Chem Lett. 2001. PMID: 11327591

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