Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.
Fearing BV, Jing L, Barcellona MN, Witte SE, Buchowski JM, Zebala LP, Kelly MP, Luhmann S, Gupta MC, Pathak A, Setton LA.
Fearing BV, et al. Among authors: pathak a.
FASEB J. 2019 Dec;33(12):14022-14035. doi: 10.1096/fj.201802725RRR. Epub 2019 Oct 22.
FASEB J. 2019.
PMID: 31638828
Free PMC article.
Such changes result in physical cues of matrix stiffness that may be potent regulators of NP cell phenotype and may contribute to a transition toward a senescent and fibroblastic NP cell with a limited capacity for repair. ...P., Kelly, M. P., Luhmann, S., Gu …
Such changes result in physical cues of matrix stiffness that may be potent regulators of NP cell phenotype and may contribute to a t …