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Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.
Gardenghi S, Marongiu MF, Ramos P, Guy E, Breda L, Chadburn A, Liu Y, Amariglio N, Rechavi G, Rachmilewitz EA, Breuer W, Cabantchik ZI, Wrighting DM, Andrews NC, de Sousa M, Giardina PJ, Grady RW, Rivella S. Gardenghi S, et al. Among authors: andrews nc. Blood. 2007 Jun 1;109(11):5027-35. doi: 10.1182/blood-2006-09-048868. Epub 2007 Feb 13. Blood. 2007. PMID: 17299088 Free PMC article.
Interleukin-6 induces hepcidin expression through STAT3.
Wrighting DM, Andrews NC. Wrighting DM, et al. Among authors: andrews nc. Blood. 2006 Nov 1;108(9):3204-9. doi: 10.1182/blood-2006-06-027631. Epub 2006 Jul 11. Blood. 2006. PMID: 16835372 Free PMC article.
Iron homeostasis and erythropoiesis.
Wrighting DM, Andrews NC. Wrighting DM, et al. Among authors: andrews nc. Curr Top Dev Biol. 2008;82:141-67. doi: 10.1016/S0070-2153(07)00006-3. Curr Top Dev Biol. 2008. PMID: 18282520 Review.
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.
Gardenghi S, Ramos P, Marongiu MF, Melchiori L, Breda L, Guy E, Muirhead K, Rao N, Roy CN, Andrews NC, Nemeth E, Follenzi A, An X, Mohandas N, Ginzburg Y, Rachmilewitz EA, Giardina PJ, Grady RW, Rivella S. Gardenghi S, et al. Among authors: andrews nc. J Clin Invest. 2010 Dec;120(12):4466-77. doi: 10.1172/JCI41717. Epub 2010 Nov 22. J Clin Invest. 2010. PMID: 21099112 Free PMC article.
227 results